Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16803631 | 0.89 | HRH3 (0.37) | HRH2HRH1HRH3 | |
| SCHEMBL12376552 | 0.79 | HTT (0.33) | LMNAL3MBTL3CHRM2CHRM4CHRM5 | |
| SCHEMBL12376563 | 0.79 | CHRM2 (0.41) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL20649067 | 0.78 | LMNA (0.34) | LMNAL3MBTL3CHRM2CHRM4CHRM5 | |
| SCHEMBL2284333 | 0.78 | BCHE (0.47) | BCHE | |
| SCHEMBL7282316 | 0.78 | L3MBTL3 (0.38) | L3MBTL3CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL1308650 | 0.78 | HRH3 (0.37) | L3MBTL3NPY1RHRH2HRH1HRH3 | |
| SCHEMBL21941322 | 0.77 | LMNA (0.39) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL16803633 | 0.77 | ACHE (0.42) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL17108654 | 0.72 | LMNA (0.34) | LMNACHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450315-B2 | Phosphoinositide 3-kinase inhibitor compounds and methods of use | GENENTECH, INC. (US) | 2013-05-28 | — | — | US | disclosed |