Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 11/20 | 0.59 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | OXTR | P30559 | 2/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17074803 | 0.87 | FAAH (0.60) | FAAHNAMPTMCHR1OXTRAVPR1A | |
| SCHEMBL28418487 | 0.83 | FAAH (0.54) | FAAHGPR119 | |
| SCHEMBL26031474 | 0.80 | FAAH (0.49) | FAAH | |
| SCHEMBL14979619 | 0.80 | FAAH (0.51) | FAAHMCHR1GPR119 | |
| SCHEMBL14979699 | 0.80 | FAAH (0.61) | FAAHNAMPT | |
| SCHEMBL10078057 | 0.77 | FAAH (0.49) | FAAH | |
| SCHEMBL6123620 | 0.77 | KDM5A (0.50) | FAAHNAMPT | |
| SCHEMBL20231733 | 0.76 | GPR119 (0.58) | FAAHGPR119 | |
| SCHEMBL22825652 | 0.76 | GPR119 (0.58) | FAAHGPR119 | |
| SCHEMBL29517804 | 0.76 | GPR119 (0.58) | FAAHGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450346-B2 | Azetidine derivatives as FAAH inhibitors | VERNALIS (R&D) LTD. (GB) | 2013-05-28 | — | — | US | disclosed |