Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 5/20 | 0.44 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.44 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.39 |
| ▸ | TPSAB1 | Q15661 | 4/20 | 0.39 |
| ▸ | TPSD1 | Q9BZJ3 | 4/20 | 0.39 |
| ▸ | TPSG1 | Q9NRR2 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15624760 | 0.88 | HTT (0.43) | ALDH1A1KDM4ENPC1SMN1; SMN2HTT | |
| SCHEMBL27336659 | 0.85 | GNAI3 (0.41) | GNAI3GNAI1GNAO1TGM2SMN1; SMN2 | |
| SCHEMBL12284392 | 0.85 | PRMT1 (0.44) | GNAI3GNAI1ALDH1A1KDM4ETGM2 | |
| SCHEMBL15355591 | 0.85 | GNAI3 (0.41) | GNAI3GNAI1GNAO1TGM2SMN1; SMN2 | |
| SCHEMBL19464837 | 0.85 | HRH3 (0.42) | GNAI3GNAI1GNAO1TGM2SMN1; SMN2 | |
| SCHEMBL21168191 | 0.84 | ATM (0.55) | ALDH1A1TGM2SMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL22620788 | 0.83 | GNAI3 (0.40) | GNAI3GNAI1GNAO1TGM2SMN1; SMN2 | |
| SCHEMBL20032529 | 0.82 | GNAI3 (0.40) | GNAI3GNAI1GNAO1TGM2SMN1; SMN2 | |
| SCHEMBL1775928 | 0.82 | GNAI3 (0.42) | GNAI3GNAI1GNAO1TGM2SMN1; SMN2 | |
| SCHEMBL12283544 | 0.82 | ALDH1A1 (0.51) | GNAI3GNAI1ALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790499-B2 | Functionally-modified oligonucleotides and subunits thereof | SAREPTA THERAPEUTICS, INC. (US) | 2017-10-17 | — | — | US | disclosed |
| US-9278987-B2 | Functionally-modified oligonucleotides and subunits thereof | SAREPTA THERAPEUTICS, INC. (US) | 2016-03-08 | — | — | US | disclosed |
| US-20140330006-A1 | FUNCTIONALLY-MODIFIED OLIGONUCLEOTIDES AND SUBUNITS THEREOF | SAREPTA THERAPEUTICS, INC. (US) | 2014-11-06 | — | — | US | disclosed |
| US-20130288369-A1 | dsRNA MOLECULES COMPRISING OLIGONUCLEOTIDE ANALOGS HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS | SAREPTA THERAPEUTICS, INC. (US) | 2013-10-31 | — | — | US | disclosed |
| WO-2013074834-A1 | FUNCTIONALLY-MODIFIED OLIGONUCLEOTIDES AND SUBUNITS THEREOF | SAREPTA THERAPEUTICS, INC. (US) | 2013-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140330006-A1 | FUNCTIONALLY-MODIFIED OLIGONUCLEOTIDES AND SUBUNITS THEREOF | RTCB, NSUN3, NSUN2 | GNAI3 1942/4885GNAI1 2223/4885GNAO1 2574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.