Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 3/20 | 0.46 |
| ▸ | IGF1R | P08069 | 3/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | INSR | P06213 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13253273 | 0.87 | MAPT (0.47) | TTKIGF1RALKSMN1; SMN2RECQL | |
| SCHEMBL309660 | 0.87 | IGF1R (0.47) | TTKIGF1RALKSMN1; SMN2RECQL | |
| Hydrochloric Acid SCHEMBL2207439 | 0.86 | IGF1R (0.47) | TTKIGF1RALKSMN1; SMN2RECQL | |
| SCHEMBL1911839 | 0.84 | INSR (0.51) | IGF1RALKACVR1ALDH1A1INSR | |
| SCHEMBL1911895 | 0.83 | L3MBTL3 (0.58) | IGF1RALKALDH1A1INSREGFR | |
| SCHEMBL310163 | 0.83 | ALDH1A1 (0.60) | IGF1RSMN1; SMN2RECQLMAPTALDH1A1 | |
| SCHEMBL1911852 | 0.82 | L3MBTL3 (0.57) | ALDH1A1 | |
| SCHEMBL10207999 | 0.81 | ALDH1A1 (0.51) | IGF1RALKACVR1ALDH1A1INSR | |
| SCHEMBL10209402 | 0.80 | KHK (0.50) | ALKTGFBR1ACVR1EGFR | |
| SCHEMBL10207550 | 0.80 | TTK (0.47) | TTKIGF1RALKACVR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188292-B1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D]PYRIMIDIN-4-YL) AMINO]BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | GLAXOSMITHKLINE IP DEV LTD (GB) | 2013-05-29 | — | — | EP | disclosed |