Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16722704 | 0.75 | NNMT (0.36) | EGFRKMT2AHTTKDM4EGAA | |
| SCHEMBL22227214 | 0.75 | CNR2 (0.36) | HTTKDM4EGAAMAPT | |
| SCHEMBL14980823 | 0.75 | NOS3 (0.35) | KMT2AKDM4EMEN1LMNAGAA | |
| SCHEMBL29431324 | 0.75 | NOS3 (0.35) | KMT2AKDM4EMEN1LMNAGAA | |
| SCHEMBL4751919 | 0.75 | NNMT (0.37) | EGFRKMT2AHTTKDM4EMEN1 | |
| SCHEMBL3619611 | 0.75 | — | — | |
| SCHEMBL31104512 | 0.75 | CNR2 (0.36) | HTTKDM4EGAAMAPT | |
| SCHEMBL24837082 | 0.71 | — | — | |
| SCHEMBL20772244 | 0.71 | NOS3 (0.35) | EGFRKMT2AHTTKDM4EMEN1 | |
| SCHEMBL20772266 | 0.71 | NNMT (0.37) | KMT2AKDM4EMEN1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2546253-B1 | SUBSTITUTED DIHYDROPYRAZOLONES FOR THE TREATMENT OF CARDIOVASCULAR AND HEMATOLOGICAL DISEASES | BAYER IP GMBH (DE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2084151-B1 | SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HAEMATOLOGICAL DISEASES | BAYER IP GMBH (DE) | 2013-05-29 | — | — | EP | disclosed |