Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29431324 | 1.00 | NOS3 (0.35) | NOS3NOS1NOS2NNMTKDM4E | |
| SCHEMBL20772266 | 0.83 | NNMT (0.37) | NOS3NOS1NOS2NNMTKDM4E | |
| SCHEMBL3620179 | 0.80 | NOS3 (0.50) | NOS3NOS1NOS2NNMTKDM4E | |
| SCHEMBL14980816 | 0.75 | EGFR (0.33) | KDM4EMAPTGAAMEN1LMNA | |
| SCHEMBL22227214 | 0.75 | CNR2 (0.36) | NNMTKDM4EMAPTALDH1A1GAA | |
| SCHEMBL31104512 | 0.75 | CNR2 (0.36) | NNMTKDM4EMAPTALDH1A1GAA | |
| SCHEMBL20772244 | 0.75 | NOS3 (0.35) | NOS3NOS1NOS2NNMTKDM4E | |
| SCHEMBL3619611 | 0.75 | — | — | |
| SCHEMBL9108295 | 0.75 | RAB9A (0.38) | NNMTMAPTALDH1A1MEN1LMNA | |
| SCHEMBL20861632 | 0.73 | L3MBTL1 (0.53) | KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3917911-A1 | 15-PGDH INHIBITORS | Kyorin Pharmaceutical Co., Ltd. (JP) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020160151-A1 | 15-PGDH INHIBITORS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2020-08-06 | — | — | WO | disclosed |
| WO-2020160151-A1 | 15-PGDH INHIBITORS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2020-08-06 | — | — | WO | disclosed |
| WO-2019043635-A1 | D-AMINO ACID OXIDASE ACTIVITY INHIBITING COMPOUNDS | RICHTER GEDEON NYRT. (HU) | 2019-03-07 | — | — | WO | disclosed |
| EP-2546253-B1 | SUBSTITUTED DIHYDROPYRAZOLONES FOR THE TREATMENT OF CARDIOVASCULAR AND HEMATOLOGICAL DISEASES | BAYER IP GMBH (DE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2084151-B1 | SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HAEMATOLOGICAL DISEASES | BAYER IP GMBH (DE) | 2013-05-29 | — | — | EP | disclosed |