Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706077 | 0.82 | CYP2C9 (0.42) | SMN1; SMN2CA2GBA1KMT2AMEN1 | |
| SCHEMBL7306016 | 0.82 | CYP2C9 (0.42) | SMN1; SMN2CA2GBA1KMT2AMEN1 | |
| SCHEMBL249120 | 0.82 | CYP2C9 (0.42) | SMN1; SMN2CA2GBA1KMT2AMEN1 | |
| SCHEMBL12524998 | 0.82 | CYP2C9 (0.42) | SMN1; SMN2CA2GBA1KMT2AMEN1 | |
| SCHEMBL12525029 | 0.82 | CYP2C9 (0.42) | SMN1; SMN2CA2GBA1KMT2AMEN1 | |
| SCHEMBL23841973 | 0.77 | CYP2C9 (0.41) | CA2KMT2ACYP2C9CYP2C19KDM4E | |
| SCHEMBL135940 | 0.74 | CA2 (0.40) | SMN1; SMN2CA2CYP2C9CYP2C19KDM4E | |
| SCHEMBL737244 | 0.64 | PRCP (0.46) | SMN1; SMN2CA2KMT2AMEN1AR | |
| SCHEMBL8107878 | 0.64 | MAOB (0.42) | CA2KMT2AMEN1KDM4EHSD17B10 | |
| SCHEMBL739240 | 0.64 | PRCP (0.46) | SMN1; SMN2CA2KMT2AMEN1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063887-B1 | NEW SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF | UNIV MICHIGAN (US) | 2013-05-29 | — | — | EP | disclosed |