Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 9/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14982882 | 0.87 | HTT (0.61) | HTTSMN1; SMN2KEAP1ALDH1A1PKM | |
| SCHEMBL20908912 | 0.78 | PKM (0.66) | HTTSMN1; SMN2KEAP1PKMKMT2A | |
| SCHEMBL14724341 | 0.77 | ALDH1A1 (0.45) | HTTSMN1; SMN2ALDH1A1GAAKMT2A | |
| SCHEMBL12285289 | 0.75 | HTT (0.62) | HTTSMN1; SMN2KEAP1ALDH1A1PKM | |
| SCHEMBL14724326 | 0.74 | HTT (0.60) | HTTSMN1; SMN2KEAP1ALDH1A1PKM | |
| SCHEMBL20908792 | 0.74 | PKM (0.67) | HTTSMN1; SMN2KEAP1ALDH1A1PKM | |
| SCHEMBL14724323 | 0.73 | HTT (0.63) | HTTSMN1; SMN2KEAP1ALDH1A1PKM | |
| SCHEMBL12285715 | 0.72 | HTT (0.58) | HTTSMN1; SMN2KEAP1ALDH1A1PKM | |
| SCHEMBL28349163 | 0.71 | HTT (0.56) | HTTSMN1; SMN2KEAP1ALDH1A1PKM | |
| SCHEMBL14982877 | 0.71 | PKM (0.61) | HTTSMN1; SMN2ALDH1A1PKMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130136794-A1 | HETEROARYL (ALKYL) DITHIOCARBAMATE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | PEKING UNIVERSITY (CN) | 2013-05-30 | — | — | US | disclosed |
| US-20130136794-A1 | HETEROARYL (ALKYL) DITHIOCARBAMATE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | PEKING UNIVERSITY (CN) | 2013-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130136794-A1 | HETEROARYL (ALKYL) DITHIOCARBAMATE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | LTK, ERBB2, ABL1 | HTT 1099/4885SMN1; SMN2 4595/4885KEAP1 1969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.