Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PKLR | P30613 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28799513 | 0.86 | GAA (0.38) | PKMPKLRHTTSMN1; SMN2CA1 | |
| SCHEMBL12692910 | 0.82 | HTT (0.45) | PKMPKLRHTTSMN1; SMN2CA1 | |
| SCHEMBL28799511 | 0.79 | CACNA1B (0.41) | SMN1; SMN2CA1CA2MMP1MMP2 | |
| SCHEMBL12543066 | 0.79 | CNR1 (0.43) | HTTSMN1; SMN2LMNAGAAHPGD | |
| SCHEMBL10476060 | 0.78 | CTSS (0.46) | PKMPKLRHTTSMN1; SMN2CA1 | |
| SCHEMBL12688354 | 0.76 | CA1 (0.47) | HTTCA1CA2MMP1MMP2 | |
| SCHEMBL1498300 | 0.76 | CA1 (0.47) | PKMPKLRHTTCA1CA2 | |
| SCHEMBL1498307 | 0.76 | RORC (0.50) | PKLRHTTSMN1; SMN2CA1CA2 | |
| Hydrochloric Acid SCHEMBL1498397 | 0.75 | CA1 (0.46) | HTTCA1CA2MMP1MMP2 | |
| SCHEMBL28133670 | 0.75 | MMP2 (0.46) | PKMPKLRHTTCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477963-A1 | ARYL SULPHONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Zalicus Pharmaceuticals Ltd. (CA) | 2012-07-25 | — | — | EP | disclosed |
| WO-2011035159-A1 | ARYL SULPHONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | ZALICUS PHARMACEUTICALS LTD. (CA) | 2011-03-24 | — | — | WO | disclosed |