Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | ULK1 | O75385 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14956498 | 0.80 | SYK (0.71) | SYKKCNH2JAK3LCKLRRK2 | |
| SCHEMBL30206568 | 0.73 | EML4 (0.53) | SYKJAK3LCKEML4ALK | |
| SCHEMBL14956373 | 0.71 | SYK (0.61) | SYKKCNH2 | |
| SCHEMBL14956375 | 0.71 | SYK (0.61) | SYKKCNH2 | |
| SCHEMBL14955333 | 0.70 | SYK (0.61) | SYKKCNH2JAK3LCKLRRK2 | |
| SCHEMBL14955581 | 0.70 | SYK (0.83) | SYKKCNH2JAK3LCKLRRK2 | |
| SCHEMBL14956546 | 0.69 | SYK (0.70) | SYKKCNH2 | |
| SCHEMBL14956548 | 0.69 | SYK (0.70) | SYKKCNH2 | |
| SCHEMBL14975962 | 0.69 | SYK (0.49) | SYKJAK3CDK2 | |
| SCHEMBL14976339 | 0.68 | RPS6KB1 (0.46) | SYKKCNH2JAK3LCKLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013078466-A1 | PYRAZINE KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | WO | disclosed |