Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.46 |
| ▸ | ESR1 | P03372 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PKLR | P30613 | 1/20 | 0.40 |
| ▸ | GALNT2 | Q10471 | 1/20 | 0.40 |
| ▸ | GALNT1 | Q10472 | 1/20 | 0.40 |
| ▸ | GALNT3 | Q14435 | 1/20 | 0.40 |
| ▸ | GALNT10 | Q86SR1 | 1/20 | 0.40 |
| ▸ | GALNT13 | Q8IUC8 | 1/20 | 0.40 |
| ▸ | GALNT6 | Q8NCL4 | 1/20 | 0.40 |
| ▸ | GALNT14 | Q96FL9 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14985659 | 0.87 | ELANE (0.45) | ELANEESR2ESR1ALDH1A1KDM4E | |
| SCHEMBL16622744 | 0.87 | ELANE (0.45) | ELANEESR2ESR1ALDH1A1KDM4E | |
| SCHEMBL18327955 | 0.79 | ALDH1A1 (0.46) | ALDH1A1KDM4ELMNAMAPTKMT2A | |
| SCHEMBL6825648 | 0.77 | ESR2 (0.77) | ESR2ESR1ALDH1A1KDM4EGAA | |
| SCHEMBL12433581 | 0.77 | CYP1A2 (0.44) | ALDH1A1KDM4ELMNAMAPTKMT2A | |
| SCHEMBL2707244 | 0.76 | NR1I2 (0.41) | ESR2ESR1ALDH1A1KDM4EMAPT | |
| SCHEMBL26766938 | 0.74 | ESR2 (0.62) | ESR2ESR1PKLRGALNT2GALNT1 | |
| SCHEMBL19793345 | 0.74 | ELANE (0.53) | ELANEALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL862799 | 0.74 | PDE2A (0.56) | ELANEESR2ESR1ALDH1A1KDM4E | |
| SCHEMBL23060994 | 0.72 | KMT2A (0.45) | ALDH1A1KDM4ELMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3309157-A1 | ANTIVIRAL COMPOUNDS | Gilead Pharmasset LLC (US) | 2018-04-18 | — | — | EP | disclosed |
| US-9511056-B2 | Antiviral compounds | GILEAD PHARMASSET LLC (US) | 2016-12-06 | — | — | US | disclosed |
| US-8841278-B2 | Antiviral compounds | GILEAD PHARMASSET LLC (US) | 2014-09-23 | — | — | US | disclosed |
| US-20140249074-A1 | ANTIVIRAL COMPOUNDS | GILEAD PHARMASSET LLC (US) | 2014-09-04 | — | — | US | disclosed |
| US-8822430-B2 | Antiviral compounds | GILEAD PHARMASSET LLC (US) | 2014-09-02 | — | — | US | disclosed |
| US-8669234-B2 | Antiviral compounds | GILEAD SCIENCES, INC. (US) | 2014-03-11 | — | — | US | disclosed |
| US-20140039021-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2014-02-06 | — | — | US | disclosed |
| US-8575118-B2 | Antiviral compounds | GILEAD SCIENCES, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-20130137877-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2013-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137877-A1 | ANTIVIRAL COMPOUNDS | MAVS, EIF2AK2, ZC3HAV1 | ELANE 1237/4885ESR2 4021/4885ESR1 4094/4885 |
| US-20140039021-A1 | ANTIVIRAL COMPOUNDS | MAVS, EIF2AK2, ZC3HAV1 | ELANE 1237/4885ESR2 4021/4885ESR1 4094/4885 |
| US-20140249074-A1 | ANTIVIRAL COMPOUNDS | MAVS, EIF2AK2, ZC3HAV1 | ELANE 1237/4885ESR2 4021/4885ESR1 4094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.