Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GGT1 | P19440 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14988934 | 0.83 | KDM4E (0.49) | PTGS2ALDH1A1PTGS1KDM4ETSHR | |
| SCHEMBL27525238 | 0.80 | METAP2 (0.52) | PTGS1TDP1METAP2METAP1ALPI | |
| SCHEMBL27525237 | 0.80 | METAP2 (0.52) | PTGS1TDP1METAP2METAP1ALPI | |
| SCHEMBL276649 | 0.79 | LTA4H (0.53) | TSHRHPGDMETAP2METAP1ANPEP | |
| SCHEMBL1841055 | 0.79 | LTA4H (0.53) | TSHRHPGDMETAP2METAP1ANPEP | |
| SCHEMBL5019109 | 0.79 | LTA4H (0.53) | TSHRHPGDMETAP2METAP1ANPEP | |
| Hydrochloric Acid SCHEMBL4634588 | 0.77 | LTA4H (0.52) | TSHRHPGDMETAP2METAP1ANPEP | |
| SCHEMBL2635410 | 0.77 | SMN1; SMN2 (0.55) | TDP1METAP2METAP1ANPEPERAP1 | |
| SCHEMBL3712742 | 0.77 | SMN1; SMN2 (0.55) | TDP1METAP2METAP1ANPEPERAP1 | |
| Hydrochloric Acid SCHEMBL17713350 | 0.77 | LTA4H (0.52) | TSHRHPGDMETAP2METAP1ANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180085333-A1 | 4-PHENYLBUTYRIC ACID DERIVATIVES | TRUOG PETER (CH) | 2018-03-29 | — | — | US | disclosed |
| US-20180085333-A1 | 4-PHENYLBUTYRIC ACID DERIVATIVES | TRUOG PETER (CH) | 2018-03-29 | — | — | US | disclosed |
| WO-2016165770-A1 | 4-PHENYLBUTYRIC ACID DERIVATIVES | TRUOG PETER (CH) | 2016-10-20 | — | — | WO | disclosed |
| EP-2599767-A1 | Phenylbutyl-derivatives | Lunamed AG (CH) | 2013-06-05 | — | — | EP | disclosed |
| EP-2599767-A1 | Phenylbutyl-derivatives | Lunamed AG (CH) | 2013-06-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180085333-A1 | 4-PHENYLBUTYRIC ACID DERIVATIVES | HTR2B, PAH, HTR1B | PTGS2 166/4885ALDH1A1 434/4885PTGS1 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.