Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.49 |
| ▸ | GGT1 | P19440 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1114384 | 0.86 | PTGS2 (0.57) | PTGS2HSD17B10KDM4ELMNACYP1A2 | |
| SCHEMBL15048752 | 0.85 | PTGS2 (0.56) | PTGS2HSD17B10KDM4ELMNACYP1A2 | |
| SCHEMBL11985691 | 0.84 | PTGS2 (0.68) | PTGS2HSD17B10KDM4ELMNACYP1A2 | |
| SCHEMBL7360282 | 0.82 | KDM4E (0.57) | HSD17B10KDM4ETDP1TSHRALDH1A1 | |
| SCHEMBL15048758 | 0.82 | PTGS2 (0.43) | PTGS2HSD17B10KDM4ELMNACYP1A2 | |
| SCHEMBL14988996 | 0.81 | PTGS2 (0.56) | PTGS2HSD17B10KDM4ETDP1TSHR | |
| SCHEMBL11985699 | 0.81 | PTGS2 (0.72) | PTGS2HSD17B10KDM4ELMNACYP1A2 | |
| SCHEMBL27409810 | 0.81 | TDP1 (0.66) | KDM4ELMNATDP1ALDH1A1MAPK1 | |
| SCHEMBL14997396 | 0.81 | ALDH1A1 (0.54) | KDM4ELMNATDP1TSHRALDH1A1 | |
| SCHEMBL1114532 | 0.80 | PTGS2 (0.64) | PTGS2HSD17B10KDM4ELMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180085333-A1 | 4-PHENYLBUTYRIC ACID DERIVATIVES | TRUOG PETER (CH) | 2018-03-29 | — | — | US | disclosed |
| US-20180085333-A1 | 4-PHENYLBUTYRIC ACID DERIVATIVES | TRUOG PETER (CH) | 2018-03-29 | — | — | US | disclosed |
| WO-2016165770-A1 | 4-PHENYLBUTYRIC ACID DERIVATIVES | TRUOG PETER (CH) | 2016-10-20 | — | — | WO | disclosed |
| EP-2599767-A1 | Phenylbutyl-derivatives | Lunamed AG (CH) | 2013-06-05 | — | — | EP | disclosed |
| EP-2599767-A1 | Phenylbutyl-derivatives | Lunamed AG (CH) | 2013-06-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180085333-A1 | 4-PHENYLBUTYRIC ACID DERIVATIVES | HTR2B, PAH, HTR1B | PTGS2 166/4885HSD17B10 239/4885KDM4E 1574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.