Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.49 |
| ▸ | CASR | P41180 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4312089 | 0.90 | AURKA (0.60) | AURKAAURKBCASRALDH1A1KDM4E | |
| SCHEMBL4312085 | 0.90 | AURKA (0.60) | AURKAAURKBCASRALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL14989099 | 0.88 | AURKB (0.56) | AURKAAURKBPLK4NTRK1 | |
| SCHEMBL14989121 | 0.87 | AURKA (0.48) | AURKAAURKBKDM4EMEN1KMT2A | |
| SCHEMBL14989004 | 0.85 | AURKA (0.58) | AURKAAURKBPLK4MAPK10EGFR | |
| SCHEMBL14989042 | 0.83 | AURKA (0.59) | AURKAAURKBMAPK10ABL1NTRK1 | |
| SCHEMBL14989235 | 0.83 | AURKA (0.56) | AURKAAURKBALDH1A1KDM4EABL1 | |
| SCHEMBL14989290 | 0.82 | AURKB (0.52) | AURKAAURKBPLK4 | |
| SCHEMBL14989122 | 0.82 | AURKA (0.57) | AURKAAURKBMAPK10ABL1NTRK1 | |
| SCHEMBL14989222 | 0.81 | AURKA (0.57) | AURKAAURKBALDH1A1PLK4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847532-B1 | IGF-1R INHIBITOR | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-06-05 | — | — | EP | claimed |