SCHEMBL14991007

SCHEMBL14991007

FC(F)(F)CCCCn1cc(I)cn1

nearest known ligand 0.37

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 1/20 0.37
JAK1 P23458 1/20 0.37
SCD5 Q86SK9 1/20 0.35
MGAT2 Q10469 3/20 0.35
FADS1 O60427 2/20 0.31
PDK2 Q15119 1/20 0.30
MOGAT2 Q3SYC2 1/20 0.30
AR P10275 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19313559 0.87 FADS1 (0.38) JAK2JAK1SCD5FADS1AR
SCHEMBL6724293 0.80
SCHEMBL15004535 0.78 MGAT2 (0.41) JAK2JAK1SCD5MGAT2PDK2
SCHEMBL18896185 0.77 MGAT2 (0.36) JAK2JAK1SCD5MGAT2FADS1
SCHEMBL18896173 0.77 MGAT2 (0.36) JAK2JAK1SCD5MGAT2FADS1
SCHEMBL2951930 0.77 L3MBTL1 (0.40)
SCHEMBL19438830 0.77 HEXA (0.30)
SCHEMBL19438827 0.77 PDK2 (0.35) JAK2JAK1PDK2
SCHEMBL2378629 0.76 AR (0.38) AR
SCHEMBL18896170 0.76 MGAT2 (0.35) JAK2JAK1SCD5MGAT2FADS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210161869-A1 ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2021-06-03 US disclosed
US-20210161869-A1 ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2021-06-03 US disclosed
US-10966967-B2 Aryl dihydropyridinones and piperidinone MGAT2 inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2021-04-06 US disclosed
US-10966967-B2 Aryl dihydropyridinones and piperidinone MGAT2 inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2021-04-06 US disclosed
US-20200281905-A1 ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2020-09-10 US disclosed
US-20200281905-A1 ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2020-09-10 US disclosed
US-10695328-B2 Aryl dihydropyridinones and piperidinone MGAT2 inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2020-06-30 US disclosed
US-10695328-B2 Aryl dihydropyridinones and piperidinone MGAT2 inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2020-06-30 US disclosed
US-20190314346-A1 ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2019-10-17 US disclosed
US-20190314346-A1 ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2019-10-17 US disclosed
US-20160031816-A1 ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2016-02-04 US disclosed
US-9187424-B1 Aryl dihydropyridinones and piperidinone MGAT2 inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2015-11-17 US disclosed
US-9187424-B1 Aryl dihydropyridinones and piperidinone MGAT2 inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2015-11-17 US disclosed
US-20150315144-A1 ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2015-11-05 US disclosed
WO-2013082345-A9 ARYL DIHYDROPYRIDINONES AND PIPERIDINONES AS MGAT2 INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2014-09-25 WO disclosed
US-8791091-B2 Aryl dihydropyridinone and piperidinone MGAT2 inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2014-07-29 US disclosed
US-8791091-B2 Aryl dihydropyridinone and piperidinone MGAT2 inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2014-07-29 US disclosed
US-20130143843-A1 ARYL DIHYDROPYRIDINONE AND PIPERIDINONE MGAT2 INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2013-06-06 US disclosed
WO-2013082345-A1 ARYL DIHYDROPYRIDINONE AND PIPERIDINONE AS MGAT2 INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2013-06-06 WO disclosed
US-20130143843-A1 ARYL DIHYDROPYRIDINONE AND PIPERIDINONE MGAT2 INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2013-06-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190314346-A1 ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS DGAT2, MGAT2, MGAT1 JAK2 2029/4885JAK1 2957/4885SCD5 637/4885
US-20130143843-A1 ARYL DIHYDROPYRIDINONE AND PIPERIDINONE MGAT2 INHIBITORS DGAT2, MGAT2, MGAT1 JAK2 2053/4885JAK1 2996/4885SCD5 610/4885
US-20160031816-A1 ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS DGAT2, MGAT2, MGAT1 JAK2 2029/4885JAK1 2957/4885SCD5 637/4885
US-20210161869-A1 ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS DGAT2, MGAT2, MGAT1 JAK2 2029/4885JAK1 2957/4885SCD5 637/4885
US-10966967-B2 Aryl dihydropyridinones and piperidinone MGAT2 inhibitors DGAT2, MGAT2, MGAT1 JAK2 2029/4885JAK1 2957/4885SCD5 637/4885
US-10695328-B2 Aryl dihydropyridinones and piperidinone MGAT2 inhibitors DGAT2, MGAT2, MGAT1 JAK2 2029/4885JAK1 2957/4885SCD5 637/4885
US-20200281905-A1 ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS DGAT2, MGAT2, MGAT1 JAK2 2029/4885JAK1 2957/4885SCD5 637/4885
US-20150315144-A1 ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS DGAT2, MGAT2, MGAT1 JAK2 2029/4885JAK1 2957/4885SCD5 637/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.