Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 8/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14996511 | 0.92 | CYP3A4 (0.68) | CYP2C9CYP2C19MAPK1MEN1KMT2A | |
| SCHEMBL13050669 | 0.92 | CYP3A4 (0.58) | CYP2C9CYP2C19MAPK1MEN1KMT2A | |
| SCHEMBL14996530 | 0.90 | CYP2C9 (0.56) | CYP2C9CYP2C19MAPK1MEN1KMT2A | |
| SCHEMBL13189834 | 0.89 | CYP2C9 (0.64) | CYP2C9CYP2C19MAPK1CYP3A4TSHR | |
| SCHEMBL25506005 | 0.86 | CYP3A4 (0.69) | CYP2C9CYP2C19MAPK1MEN1KMT2A | |
| SCHEMBL11947914 | 0.84 | CYP3A4 (0.67) | CYP2C9CYP2C19MAPK1MEN1KMT2A | |
| SCHEMBL14996507 | 0.84 | CYP2C9 (0.58) | CYP2C9CYP2C19MAPK1CYP3A4TSHR | |
| SCHEMBL14996490 | 0.84 | CYP2C9 (0.63) | CYP2C9CYP2C19MAPK1MEN1KMT2A | |
| SCHEMBL14996494 | 0.84 | CYP3A4 (0.65) | CYP2C9CYP2C19MAPK1MEN1KMT2A | |
| SCHEMBL15237604 | 0.83 | TSHR (0.57) | CYP2C9CYP2C19MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | disclosed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | BDKRB1, BDKRB2, REN | CYP2C9 2259/4885CYP2C19 2325/4885MAPK1 1001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.