Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 15/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 9/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.68 |
| ▸ | TSHR | P16473 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14996490 | 0.92 | CYP2C9 (0.63) | CYP3A4CYP2C19CYP2C9CYP2D6TSHR | |
| SCHEMBL14996493 | 0.92 | CYP2C9 (0.57) | CYP3A4CYP2C19CYP2C9CYP2D6TSHR | |
| SCHEMBL14996512 | 0.88 | CYP3A4 (0.64) | CYP3A4CYP2C19CYP2C9CYP2D6TSHR | |
| SCHEMBL14996494 | 0.86 | CYP3A4 (0.65) | CYP3A4CYP2C19CYP2C9CYP2D6TSHR | |
| SCHEMBL15237604 | 0.86 | TSHR (0.57) | CYP3A4CYP2C19CYP2C9CYP2D6TSHR | |
| SCHEMBL25506005 | 0.85 | CYP3A4 (0.69) | CYP3A4CYP2C19CYP2C9CYP2D6TSHR | |
| SCHEMBL15237591 | 0.84 | CYP2C9 (0.62) | CYP3A4CYP2C19CYP2C9CYP2D6TSHR | |
| SCHEMBL13050669 | 0.84 | CYP3A4 (0.58) | CYP3A4CYP2C19CYP2C9CYP2D6TSHR | |
| SCHEMBL11947860 | 0.84 | CYP2C9 (0.64) | CYP3A4CYP2C19CYP2C9CYP2D6TSHR | |
| SCHEMBL11955029 | 0.84 | CYP2C19 (0.64) | CYP3A4CYP2C19CYP2C9CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | disclosed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | BDKRB1, BDKRB2, REN | CYP3A4 3781/4885CYP2C19 2325/4885CYP2C9 2259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.