Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 6/20 | 0.38 |
| ▸ | HTR6 | P50406 | 4/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28026351 | 1.00 | HTR1A (0.39) | HTR1ASLC6A2SLC6A4SLC6A3IDO1 | |
| SCHEMBL10036999 | 0.89 | ADRA1A (0.35) | HTR1ASLC6A2SLC6A4SLC6A3IDO1 | |
| SCHEMBL28139518 | 0.80 | CYP19A1 (0.38) | HTR1ASLC6A2SLC6A4SLC6A3IDO1 | |
| SCHEMBL25791837 | 0.80 | HTR1A (0.38) | HTR1ASLC6A2SLC6A4SLC6A3IDO1 | |
| SCHEMBL30320409 | 0.80 | IDO1 (0.42) | HTR1ASLC6A2SLC6A4SLC6A3IDO1 | |
| SCHEMBL25793903 | 0.77 | HTR1A (0.37) | HTR1ASLC6A2SLC6A4SLC6A3IDO1 | |
| SCHEMBL25791511 | 0.77 | HTR1A (0.37) | HTR1ASLC6A2SLC6A4SLC6A3IDO1 | |
| SCHEMBL30972618 | 0.76 | HTR1A (0.39) | HTR1ASLC6A2SLC6A4SLC6A3IDO1 | |
| SCHEMBL29864687 | 0.76 | IDO1 (0.38) | HTR1ASLC6A2SLC6A4SLC6A3IDO1 | |
| SCHEMBL27904400 | 0.76 | CHRNB4 (0.31) | HTR1ASLC6A2SLC6A4SLC6A3CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791106-B2 | Fused ring pyridine compound | ASTELLAS PHARMA INC. (JP) | 2014-07-29 | — | — | US | disclosed |
| US-8791106-B2 | Fused ring pyridine compound | ASTELLAS PHARMA INC. (JP) | 2014-07-29 | — | — | US | disclosed |
| US-20130143874-A1 | FUSED RING PYRIDINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-06-06 | — | — | US | disclosed |
| US-20130143874-A1 | FUSED RING PYRIDINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130143874-A1 | FUSED RING PYRIDINE COMPOUND | CNR2, CNR1, TRPV1 | HTR1A 299/4885SLC6A2 3389/4885SLC6A4 3290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.