Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | LARS1 | Q9P2J5 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TARS1 | P26639 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3097100 | 0.87 | GAA (0.53) | GAALARS1ALDH1A1LMNAHPGD | |
| SCHEMBL3085973 | 0.85 | LARS1 (0.53) | LARS1ALDH1A1LMNAHPGDKDM4E | |
| SCHEMBL15000139 | 0.85 | ALDH1A1 (0.46) | LARS1ALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL14999974 | 0.84 | LARS1 (0.49) | LARS1ALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL14999959 | 0.83 | TARS1 (0.52) | ALDH1A1LMNAMEN1KMT2ATARS1 | |
| SCHEMBL3088272 | 0.83 | MMP8 (0.60) | GAALARS1ALDH1A1OPRK1LMNA | |
| SCHEMBL15000273 | 0.82 | BCL2 (0.48) | LMNASMN1; SMN2MEN1KMT2AMMP2 | |
| SCHEMBL15000281 | 0.82 | F2 (0.49) | LARS1 | |
| SCHEMBL14999926 | 0.81 | SLC16A3 (0.49) | LARS1ALDH1A1OPRK1MAPTALOX5 | |
| SCHEMBL15000040 | 0.81 | ALDH1A1 (0.49) | GAAALDH1A1LMNAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461209-B2 | Malonic acid sulfonamide derivative and pharmaceutical use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2013-06-11 | — | — | US | disclosed |