SCHEMBL1500477

SCHEMBL1500477

SC(Cl)(Cl)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.58
CYP1A2 P05177 1/20 0.52
KCNN4 O15554 5/20 0.43
ALDH1A1 P00352 2/20 0.43
PTPN1 P18031 1/20 0.39
MAPK1 P28482 1/20 0.38
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA5A P35218 1/20 0.37
CA9 Q16790 1/20 0.37
MAPT P10636 1/20 0.37
KMT2A Q03164 1/20 0.37
PGK1 P00558 1/20 0.36
PGK2 P07205 1/20 0.36
CYP2C19 P33261 1/20 0.36
HIF1A Q16665 1/20 0.36
TAAR1 Q96RJ0 1/20 0.35
ALOX15 P16050 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10594103 0.77 TSHR (0.52) TSHRCYP1A2KCNN4ALDH1A1MAPK1
SCHEMBL15125000 0.76 CYP1A2 (0.60) TSHRCYP1A2KCNN4ALDH1A1PTPN1
SCHEMBL7381727 0.75 TSHR (0.58) TSHRCYP1A2KCNN4ALDH1A1PTPN1
SCHEMBL11686299 0.75 TSHR (0.58) TSHRCYP1A2KCNN4ALDH1A1PTPN1
SCHEMBL1831719 0.75 TSHR (0.58) TSHRCYP1A2KCNN4ALDH1A1PTPN1
Triphenylmethanethiol SCHEMBL34008 0.73 KCNN4 (0.47) TSHRCYP1A2KCNN4ALDH1A1PTPN1
SCHEMBL6886213 0.73 KCNN4 (0.47) TSHRCYP1A2KCNN4ALDH1A1PTPN1
SCHEMBL812227 0.73 KCNN4 (0.47) TSHRCYP1A2KCNN4ALDH1A1PTPN1
SCHEMBL151981 0.73 TSHR (0.65) TSHRCYP1A2KCNN4ALDH1A1PTPN1
Chlorotriphenylmethane SCHEMBL461 0.73 TSHR (0.65) TSHRCYP1A2KCNN4ALDH1A1PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116438214-A Sealing material for organic EL display element, cured product thereof, and organic EL display device 三井化学株式会社 2023-07-14 CN disclosed
WO-2022107692-A1 SEALING MATERIAL FOR ORGANIC EL DISPLAY ELEMENT, CURED PRODUCT OF SAID SEALING MATERIAL, AND ORGANIC EL DISPLAY DEVICE 三井化学株式会社 2022-05-27 WO disclosed
US-20110160082-A1 Mobility-Modified Nucleobase Polymers and Methods of Using Same Life Technologies Corporation (US) 2011-06-30 US disclosed
US-7897338-B2 Mobility-modified nucleobase polymers and methods of using same APPLIED BIOSYSTEMS, LLC (US) 2011-03-01 US disclosed
EP-1379698-A4 MOBILITY-MODIFIED NUCLEOBASE POLYMERS AND METHODS OF USING SAME APPLERA CORP (US) 2007-04-25 EP disclosed
US-20070026434-A1 Mobility-Modified Nucleobase Polymers and Methods of Using Same APPLERA CORPORATION (US) 2007-02-01 US disclosed
US-7074569-B2 contacting a target nucleic acids with the nucleobase polymers under conditions that distinguish those nucleobase polymers that hybridize to the target nucleic acid; phosphoramidite reagents which can be joined to other mobility-modifying monomers and to sequence-specific oligonucleobase polymers APPLERA CORPORATION (US) 2006-07-11 US disclosed
US-20050042644-A1 Mobility-modified nucleobase polymers and methods of using same APPLERA CORPORATION (US) 2005-02-24 US disclosed
US-6743905-B2 BIOPOLYMER FOR USE IN THE DETECTION OF PREERENTIAL SEQUENCES IN SAMPLE APPLERA CORPORATION 2004-06-01 US disclosed
EP-1379698-A1 MOBILITY-MODIFIED NUCLEOBASE POLYMERS AND METHODS OF USING SAME Applera Corporation (US) 2004-01-14 EP disclosed
US-20020182602-A1 Mobility-modified nucleobase polymers and methods of using same APPLIED BIOSYSTEMS, INC. 2002-12-05 US disclosed
WO-2002083954-A1 MOBILITY-MODIFIED NUCLEOBASE POLYMERS AND METHODS OF USING SAME APPLERA CORPORATION (US) 2002-10-24 WO disclosed
US-5962291-A MONOCLONAL ANTIBODY CAPABLE OF HYDROLYZING A SUBSTRATE; HAS TWO BINDING SITES: ONE FOR FREE METAL ION, ONE FOR SUBSTRATE THE REGENTS OF THE UNIVERSITY OF COLORADO (US) 1999-10-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070026434-A1 Mobility-Modified Nucleobase Polymers and Methods of Using Same PCNA, PNKP, SAMHD1 TSHR 3939/4885CYP1A2 4879/4885KCNN4 3803/4885
US-20020182602-A1 Mobility-modified nucleobase polymers and methods of using same PCNA, PNKP, SAMHD1 TSHR 3939/4885CYP1A2 4879/4885KCNN4 3803/4885
US-20110160082-A1 Mobility-Modified Nucleobase Polymers and Methods of Using Same PCNA, PNKP, SAMHD1 TSHR 3939/4885CYP1A2 4879/4885KCNN4 3803/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.