Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 8/20 | 0.41 |
| ▸ | CNR2 | P34972 | 5/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1500704 | 1.00 | MGLL (0.42) | MGLLOPRD1CNR1CNR2CYP2D6 | |
| SCHEMBL1500612 | 0.81 | MGLL (0.43) | MGLLOPRD1CNR1CNR2CYP2D6 | |
| SCHEMBL1500614 | 0.81 | MGLL (0.43) | MGLLOPRD1CNR1CNR2CYP2D6 | |
| SCHEMBL1500553 | 0.80 | CYP2D6 (0.53) | MGLLOPRD1CYP2D6CYP19A1ADRA1A | |
| Bromide SCHEMBL3300210 | 0.78 | CYP2D6 (0.52) | MGLLOPRD1CYP2D6CYP19A1ADRA1A | |
| SCHEMBL3670679 | 0.77 | MGLL (0.43) | MGLLCNR1CNR2SLC6A2SLC6A4 | |
| SCHEMBL3670680 | 0.77 | MGLL (0.43) | MGLLCNR1CNR2SLC6A2SLC6A4 | |
| SCHEMBL6011569 | 0.75 | CNR1 (0.43) | MGLLCNR1CNR2 | |
| SCHEMBL1528945 | 0.74 | CNR1 (0.39) | MGLLCNR1CNR2ADRA1ACHRM2 | |
| SCHEMBL1528612 | 0.74 | CNR1 (0.44) | CNR1CNR2ADRA1AADRA1DADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906652-B2 | Heterocycle-substituted 3-alkyl azetidine derivatives | MERCK SHARP & DOHME CORP. (US) | 2011-03-15 | — | — | US | disclosed |
| US-20100081642-A1 | CB-1 RECEPTOR MODULATOR PHARMACEUTICAL FORMULATIONS | MERCK SHARP & DOHME CORP. | 2010-04-01 | — | — | US | disclosed |
| US-20070123505-A1 | Heterocycle-substituted 3-alkyl azetidine derivatives | MERCK SHARP & DOHME CORP. | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123505-A1 | Heterocycle-substituted 3-alkyl azetidine derivatives | CNR1, CNR2, FAAH | MGLL 444/4885OPRD1 81/4885CNR1 1/4885 |
| US-20100081642-A1 | CB-1 RECEPTOR MODULATOR PHARMACEUTICAL FORMULATIONS | CNR1, CNR2, GPBAR1 | MGLL 625/4885OPRD1 62/4885CNR1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.