Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RBP1 | P09455 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15014518 | 0.90 | RAB9A (0.49) | RAB9ANPC1MITFALDH1A1MEN1 | |
| SCHEMBL12424279 | 0.84 | RBP1 (0.45) | RAB9ANPC1MITFALDH1A1MEN1 | |
| SCHEMBL12384751 | 0.83 | RAB9A (0.42) | RAB9ANPC1MITFALDH1A1MEN1 | |
| SCHEMBL12519914 | 0.82 | RAB9A (0.56) | RAB9ANPC1MITFALDH1A1MEN1 | |
| SCHEMBL8352583 | 0.81 | RAB9A (0.59) | RAB9ANPC1MITFALDH1A1MEN1 | |
| SCHEMBL8348678 | 0.79 | SMN1; SMN2 (0.60) | RAB9ANPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL15014608 | 0.79 | RAB9A (0.40) | RAB9ANPC1MITFALDH1A1MEN1 | |
| SCHEMBL16303842 | 0.78 | SMN1; SMN2 (0.42) | RAB9ANPC1MITFALDH1A1SMN1; SMN2 | |
| SCHEMBL12384487 | 0.77 | POLB (0.45) | RAB9ANPC1MITFALDH1A1MEN1 | |
| SCHEMBL12424346 | 0.74 | ALDH1A1 (0.36) | RAB9ANPC1MITFALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461328-B2 | Tricyclic heterocyclic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2013-06-11 | — | — | US | disclosed |