Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6978728 | 0.82 | CREBBP (0.63) | CREBBPBRD4 | |
| SCHEMBL30417761 | 0.82 | CREBBP (0.63) | CREBBPBRD4 | |
| SCHEMBL19987645 | 0.80 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AL3MBTL1CREBBP | |
| SCHEMBL28923894 | 0.78 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AL3MBTL1CREBBP | |
| SCHEMBL23010557 | 0.78 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AL3MBTL1CREBBP | |
| SCHEMBL4552573 | 0.78 | TSHR (0.54) | ALDH1A1MEN1KMT2AL3MBTL1LMNA | |
| Naphthalene SCHEMBL7006954 | 0.76 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2AL3MBTL1CREBBP | |
| SCHEMBL16229051 | 0.75 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2AL3MBTL1LMNA | |
| Naphthalene SCHEMBL7009617 | 0.75 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2AL3MBTL1CREBBP | |
| Naphthalene SCHEMBL2230173 | 0.75 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2AL3MBTL1CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2291355-A2 | NOVEL TETRAHYDROQUINOLINES AS AROMATASE INHIBITORS | Panjab University (IN) | 2011-03-09 | — | — | EP | claimed |
| US-20100280070-A1 | NOVEL TETRAHYDROQUINOLINES AS AROMATASE INHIBITORS | AKKINEPALLY RAGHURAM RAO | 2010-11-04 | — | — | US | claimed |
| WO-2009087684-A2 | NOVEL TETRAHYDROQUINOLINES AS AROMATASE INHIBITORS | PANJAB UNIVERSITY (IN) | 2009-07-16 | — | — | WO | claimed |
| EP-2291355-A2 | NOVEL TETRAHYDROQUINOLINES AS AROMATASE INHIBITORS | Panjab University (IN) | 2011-03-09 | — | — | EP | disclosed |
| US-20100280070-A1 | NOVEL TETRAHYDROQUINOLINES AS AROMATASE INHIBITORS | AKKINEPALLY RAGHURAM RAO | 2010-11-04 | — | — | US | disclosed |
| WO-2009087684-A2 | NOVEL TETRAHYDROQUINOLINES AS AROMATASE INHIBITORS | PANJAB UNIVERSITY (IN) | 2009-07-16 | — | — | WO | disclosed |
| EP-1292575-A2 | 1-ARYL-4-OXO-1,4-DIHYDRO-3-QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001098275-A2 | 1-ARYL-4-OXO-1,4-DIHYDRO-3-QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2001-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280070-A1 | NOVEL TETRAHYDROQUINOLINES AS AROMATASE INHIBITORS | CYP19A1, HSD17B11, CYP17A1 | ALDH1A1 277/4885MEN1 1057/4885KMT2A 539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.