Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 8/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.46 |
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | ICMT | O60725 | 1/20 | 0.39 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.38 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13531373 | 0.90 | NPC1 (0.44) | CYP11B1CYP11B2IDO1HPGDSKDM4E | |
| SCHEMBL15435450 | 0.88 | CYP11B1 (0.52) | CYP11B1CYP11B2IDO1HPGDSICMT | |
| SCHEMBL1502220 | 0.85 | CYP11B1 (0.47) | CYP11B1CYP11B2IDO1HPGDSSLC16A3 | |
| SCHEMBL1948994 | 0.84 | CYP11B1 (0.60) | CYP11B1CYP11B2IDO1HPGDSALDH1A1 | |
| SCHEMBL1501829 | 0.81 | CYP11B1 (0.38) | CYP11B1CYP11B2IDO1HPGDSICMT | |
| SCHEMBL1949967 | 0.81 | KDM5B (0.42) | CYP11B1CYP11B2IDO1KDM5BKDM4E | |
| SCHEMBL1501932 | 0.80 | IDO1 (0.50) | CYP11B1CYP11B2IDO1HSP90AA1HSP90AB1 | |
| SCHEMBL10988081 | 0.73 | CYP11B1 (0.58) | CYP11B1CYP11B2IDO1KDM4EALDH1A1 | |
| SCHEMBL20485754 | 0.73 | FYN (0.46) | CYP11B1CYP11B2KDM4EALDH1A1HSP90AA1 | |
| SCHEMBL1502360 | 0.73 | ALOX15 (0.41) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174942-B2 | IDO inhibitors | NEWLINK GENETICS CORPORATION (US) | 2015-11-03 | — | — | US | disclosed |
| US-20140323740-A1 | IDO Inhibitors | NEWLINK GENETICS CORPORATION (US) | 2014-10-30 | — | — | US | disclosed |
| US-8748469-B2 | IDO inhibitors | NEWLINK GENETICS CORPORATION (US) | 2014-06-10 | — | — | US | disclosed |
| US-20110136796-A1 | IDO Inhibitors | NEWLINK GENETICS (US) | 2011-06-09 | — | — | US | disclosed |
| EP-2291187-A2 | IDO INHIBITORS | Newlink Genetics (US) | 2011-03-09 | — | — | EP | disclosed |
| WO-2009132238-A2 | IDO INHIBITORS | NEWLINK GENETICS (US) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323740-A1 | IDO Inhibitors | IDO1, IDO2, INMT | CYP11B1 1122/4885CYP11B2 1149/4885IDO1 1/4885 |
| US-20110136796-A1 | IDO Inhibitors | IDO1, IDO2, INMT | CYP11B1 1122/4885CYP11B2 1149/4885IDO1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.