Sugi Predict

Sugi Predict / Compounds / SCHEMBL1948994

SCHEMBL1948994

SCHEMBL1948994

CC(C)Cn1cncc1-c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP11B1 P15538 8/20 0.60
▸ CYP11B2 P19099 8/20 0.60
▸ IDO1 P14902 4/20 0.60
▸ HPGDS O60760 2/20 0.48
▸ LDLR P01130 1/20 0.42
▸ PCSK9 Q8NBP7 1/20 0.42
▸ HSP90AA1 P07900 1/20 0.41
▸ HSP90AB1 P08238 1/20 0.41
▸ BRD9 Q9H8M2 1/20 0.38
▸ KCNH2 Q12809 2/20 0.38
▸ LMNA P02545 1/20 0.38
▸ POLB P06746 1/20 0.38
▸ HRH2 P25021 1/20 0.38
▸ ADRA1D P25100 1/20 0.38
▸ HTR2A P28223 1/20 0.38
▸ ADORA2A P29274 1/20 0.38
▸ ADRA1A P35348 1/20 0.38
▸ NUDT1 P36639 1/20 0.38
▸ HTR2B P41595 1/20 0.38
▸ PDE4D Q08499 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15435450 0.88 CYP11B1 (0.52) CYP11B1CYP11B2IDO1HPGDSALDH1A1
SCHEMBL29352305 0.84 CYP11B1 (0.46) CYP11B1CYP11B2IDO1HPGDSHSP90AA1
SCHEMBL1502376 0.84 CYP11B1 (0.46) CYP11B1CYP11B2IDO1HPGDSHSP90AA1
SCHEMBL21872252 0.83 CYP11B1 (0.57) CYP11B1CYP11B2IDO1HPGDSLDLR
SCHEMBL10989241 0.83 IDO1 (0.45) CYP11B1CYP11B2IDO1HSP90AA1HSP90AB1
SCHEMBL1501932 0.82 IDO1 (0.50) CYP11B1CYP11B2IDO1HSP90AA1HSP90AB1
SCHEMBL10988081 0.81 CYP11B1 (0.58) CYP11B1CYP11B2IDO1HSP90AA1HSP90AB1
SCHEMBL1502220 0.80 CYP11B1 (0.47) CYP11B1CYP11B2IDO1HPGDS
SCHEMBL1501902 0.80 CYP11B1 (0.66) CYP11B1CYP11B2IDO1HPGDSLDLR
SCHEMBL21630287 0.80 CYP11B1 (0.53) CYP11B1CYP11B2IDO1HPGDSLDLR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4584259-A1 CK1ALPHA AND DUAL CK1ALPHA / GSPT1 DEGRADING COMPOUNDS Innovo Therapeutics, Inc. (US) 2025-07-16 — — EP disclosed
US-20240158370-A1 CK1 alpha AND DUAL CK1 alpha / GSPT1 DEGRADING COMPOUNDS INNOVO THERAPEUTICS, INC. 2024-05-16 — — US disclosed
WO-2024054832-A1 CK1α AND DUAL CK1α / GSPT1 DEGRADING COMPOUNDS INNOVO THERAPEUTICS, INC. (US) 2024-03-14 — — WO disclosed
US-20230002327-A1 SMALL-MOLECULE REGULATOR OF TLR8 TSINGHUA UNIVERSITY (CN) 2023-01-05 — — US disclosed
US-20230002327-A1 SMALL-MOLECULE REGULATOR OF TLR8 TSINGHUA UNIVERSITY (CN) 2023-01-05 — — US disclosed
CN-112174903-B Small molecule modulators of TLR8 清华大学 2022-07-12 — — CN disclosed
EP-3998255-A1 SMALL-MOLECULE REGULATOR OF TLR8 Tsinghua University (CN) 2022-05-18 — — EP disclosed
EP-3998255-A1 SMALL-MOLECULE REGULATOR OF TLR8 Tsinghua University (CN) 2022-05-18 — — EP disclosed
WO-2021000755-A1 SMALL-MOLECULE REGULATOR OF TLR8 清华大学 2021-01-07 — — WO disclosed
WO-2021000755-A1 SMALL-MOLECULE REGULATOR OF TLR8 清华大学 2021-01-07 — — WO disclosed
US-20140343006-A1 HIV Replication Inhibiting Pyrimidines JANSSEN PHARMACEUTICA NV (NL) 2014-11-20 — — US disclosed
US-20140323740-A1 IDO Inhibitors NEWLINK GENETICS CORPORATION (US) 2014-10-30 — — US disclosed
US-8828982-B2 Pyrimidine derivatives for the prevention of HIV infection JANSSEN PHARMACEUTICA N.V. (BE) 2014-09-09 — — US disclosed
US-8748469-B2 IDO inhibitors NEWLINK GENETICS CORPORATION (US) 2014-06-10 — — US disclosed
US-20120076835-A1 HIV INHIBITING PYRIMIDINES DERIVATIVES GUILLEMONT JEROME EMILE GEORGES (FR) 2012-03-29 — — US disclosed
US-8080551-B2 HIV inhibiting pyrimidines derivatives JANSSEN PHARMACEUTICA N.V. (BE) 2011-12-20 — — US disclosed
US-8080551-B2 HIV inhibiting pyrimidines derivatives JANSSEN PHARMACEUTICA N.V. (BE) 2011-12-20 — — US disclosed
US-20110136796-A1 IDO Inhibitors NEWLINK GENETICS (US) 2011-06-09 — — US disclosed
US-20100034810-A1 PYRIMIDINE DERIVATIVES FOR THE PREVENTION OF HIV INFECTION JANSSEN-CILAG (FR) 2010-02-11 — — US disclosed
US-20070021449-A1 Pyrimidine derivatives for the prevention of hiv infection HEERES JAN 2007-01-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140343006-A1 HIV Replication Inhibiting Pyrimidines RRM2B, CCNO, RRM2 CYP11B1 715/4885CYP11B2 1015/4885IDO1 752/4885
US-20070021449-A1 Pyrimidine derivatives for the prevention of hiv infection ADORA2B, CYP1B1, DPYD CYP11B1 360/4885CYP11B2 537/4885IDO1 107/4885
US-20240158370-A1 CK1 alpha AND DUAL CK1 alpha / GSPT1 DEGRADING COMPOUNDS CKS1B, CKS2, MARK1 CYP11B1 2054/4885CYP11B2 2911/4885IDO1 1901/4885
US-20120076835-A1 HIV INHIBITING PYRIMIDINES DERIVATIVES TYMS, PNP, DUT CYP11B1 716/4885CYP11B2 893/4885IDO1 145/4885
US-20140323740-A1 IDO Inhibitors IDO1, IDO2, INMT CYP11B1 1122/4885CYP11B2 1149/4885IDO1 1/4885
US-20100034810-A1 PYRIMIDINE DERIVATIVES FOR THE PREVENTION OF HIV INFECTION NOX3, CBR3, CBR1 CYP11B1 116/4885CYP11B2 163/4885IDO1 934/4885
US-20110136796-A1 IDO Inhibitors IDO1, IDO2, INMT CYP11B1 1122/4885CYP11B2 1149/4885IDO1 1/4885
US-20230002327-A1 SMALL-MOLECULE REGULATOR OF TLR8 TLR8, TLR6, TLR1 CYP11B1 3957/4885CYP11B2 3816/4885IDO1 2707/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.