Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 20/20 | 0.52 |
| ▸ | UBA3 | Q8TBC4 | 20/20 | 0.52 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.30 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15958749 | 0.91 | NAE1 (0.55) | NAE1UBA3 | |
| SCHEMBL15025759 | 0.90 | NAE1 (0.51) | NAE1UBA3 | |
| SCHEMBL16376870 | 0.89 | NAE1 (0.66) | NAE1UBA3 | |
| SCHEMBL14719789 | 0.80 | NAE1 (0.68) | NAE1UBA3 | |
| SCHEMBL29484028 | 0.80 | NAE1 (0.68) | NAE1UBA3 | |
| SCHEMBL14723085 | 0.80 | NAE1 (0.68) | NAE1UBA3 | |
| Hydrochloric Acid SCHEMBL14719845 | 0.80 | NAE1 (0.67) | NAE1UBA3 | |
| SCHEMBL14723289 | 0.79 | NAE1 (0.53) | NAE1UBA3 | |
| SCHEMBL783523 | 0.79 | NAE1 (0.80) | NAE1UBA3 | |
| SCHEMBL14719844 | 0.78 | NAE1 (0.51) | NAE1UBA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809356-B2 | Inhibitors of NEDD8-activating enzyme | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-08-19 | — | — | US | disclosed |
| US-20130150388-A1 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150388-A1 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | NEDD8, NAE1, UBA3 | NAE1 2/4885UBA3 3/4885SAE1 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.