SCHEMBL1502579

SCHEMBL1502579

COC(=O)c1ccc(CNc2nc(Cl)nc3cccc(-c4ccccc4)c23)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 5/20 0.57
JAK2 O60674 1/20 0.57
IGF1R P08069 1/20 0.57
PIM1 P11309 1/20 0.57
SRC P12931 1/20 0.57
CSNK2A2 P19784 1/20 0.57
JAK1 P23458 1/20 0.57
CCNE1 P24864 1/20 0.57
CDK2 P24941 1/20 0.57
TYK2 P29597 1/20 0.57
FLT4 P35916 1/20 0.57
FLT3 P36888 1/20 0.57
MAP3K8 P41279 1/20 0.57
CSNK1A1 P48729 1/20 0.57
GSK3B P49841 1/20 0.57
JAK3 P52333 1/20 0.57
PLK1 P53350 1/20 0.57
CSNK2A1 P68400 1/20 0.57
CDK5 Q00535 1/20 0.57
BTK Q06187 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7258124 0.86 DRD2 (0.50) KCNA5JAK2IGF1RPIM1SRC
SCHEMBL12170718 0.86 KCNA5 (0.65) KCNA5JAK2IGF1RPIM1SRC
SCHEMBL1502698 0.85 KCNA5 (0.61) KCNA5JAK2CSNK2A2CCNE1CDK2
SCHEMBL19820795 0.85 KCNA5 (0.59) KCNA5JAK2IGF1RPIM1SRC
SCHEMBL18437054 0.85 KCNA5 (0.61) KCNA5JAK2IGF1RPIM1SRC
SCHEMBL12170176 0.85 KCNA5 (0.61) KCNA5JAK2IGF1RPIM1SRC
SCHEMBL12170035 0.84 KCNA5 (0.72) KCNA5JAK2IGF1RPIM1SRC
SCHEMBL12170196 0.84 KCNA5 (0.73) KCNA5JAK2IGF1RPIM1SRC
SCHEMBL12833242 0.84 ESR1 (0.65) KCNA5JAK2IGF1RPIM1SRC
SCHEMBL12170179 0.84 KCNA5 (0.65) KCNA5JAK2IGF1RPIM1SRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250230144-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2025-07-17 US disclosed
US-20230322726-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2023-10-12 US disclosed
US-20230322726-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2023-10-12 US disclosed
US-20220324836-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2022-10-13 US disclosed
EP-3575288-B1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2021-10-27 EP disclosed
EP-3575288-B1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2021-10-27 EP disclosed
US-11008306-B2 Quinazolines as potassium ion channel inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2021-05-18 US disclosed
US-11008306-B2 Quinazolines as potassium ion channel inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2021-05-18 US disclosed
US-20200255407-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2020-08-13 US disclosed
US-20200255407-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2020-08-13 US disclosed
US-20140031345-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2014-01-30 US disclosed
US-8575184-B2 Quinazolines as potassium ion channel inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2013-11-05 US disclosed
US-8575184-B2 Quinazolines as potassium ion channel inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2013-11-05 US disclosed
US-8575184-B2 Quinazolines as potassium ion channel inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2013-11-05 US disclosed
US-20120232068-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTON-MYERS SQUIBB COMPANY (US) 2012-09-13 US disclosed
US-20120232068-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTON-MYERS SQUIBB COMPANY (US) 2012-09-13 US disclosed
US-20120232068-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTON-MYERS SQUIBB COMPANY (US) 2012-09-13 US disclosed
EP-2473487-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS Bristol-Myers Squibb Company (US) 2012-07-11 EP disclosed
WO-2011028741-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2011-03-10 WO disclosed
WO-2011028741-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2011-03-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220324836-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS KCNJ4, KCNK4, KCNQ4 KCNA5 48/4885JAK2 3314/4885IGF1R 2755/4885
US-20250230144-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS KCNJ4, KCNK4, KCNQ4 KCNA5 48/4885JAK2 3314/4885IGF1R 2755/4885
US-20200255407-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS KCNJ4, KCNK4, KCNQ4 KCNA5 48/4885JAK2 3314/4885IGF1R 2755/4885
US-20120232068-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS KCNJ4, KCNH3, KCNQ4 KCNA5 46/4885JAK2 3120/4885IGF1R 2921/4885
US-11008306-B2 Quinazolines as potassium ion channel inhibitors KCNJ4, KCNK4, KCNQ4 KCNA5 48/4885JAK2 3314/4885IGF1R 2755/4885
US-20140031345-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS KCNJ4, KCNK4, KCNQ4 KCNA5 48/4885JAK2 3314/4885IGF1R 2755/4885
US-20230322726-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS KCNJ4, KCNK4, KCNQ4 KCNA5 48/4885JAK2 3314/4885IGF1R 2755/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.