Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 9/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12069096 | 0.89 | SLC22A12 (0.68) | SLC22A12 | |
| SCHEMBL15025884 | 0.82 | SLC22A12 (0.57) | SLC22A12POLB | |
| SCHEMBL15163965 | 0.81 | SLC22A12 (0.81) | SLC22A12 | |
| SCHEMBL15025968 | 0.81 | SLC22A12 (0.53) | SLC22A12 | |
| SCHEMBL15025886 | 0.79 | SLC22A12 (0.57) | SLC22A12 | |
| SCHEMBL15025979 | 0.79 | SLC22A12 (0.55) | SLC22A12 | |
| SCHEMBL28869486 | 0.79 | MKNK1 (0.51) | MKNK1MKNK2CHEK2MAPTPOLB | |
| SCHEMBL28264223 | 0.74 | MKNK1 (0.61) | MKNK1MKNK2PDK2CHEK2MAPT | |
| SCHEMBL30231796 | 0.73 | SIRT1 (0.56) | SLC22A12MKNK1MKNK2CHEK2MAPT | |
| SCHEMBL15025963 | 0.71 | MKNK1 (0.42) | SLC22A12MKNK1MKNK2PDK2CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9212135-B2 | Phenylthioacetate compounds, compositions and methods of use | ARDEA BIOSCIENCES, INC. (US) | 2015-12-15 | — | — | US | disclosed |
| US-20150322006-A1 | PHENYLTHIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES, INC. | 2015-11-12 | — | — | US | disclosed |
| US-20130150381-A1 | PHENYLTHIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCE, INC. (US) | 2013-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150381-A1 | PHENYLTHIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | MPST, PON1, NUDT1 | SLC22A12 628/4885MKNK1 3664/4885MKNK2 3984/4885 |
| US-20150322006-A1 | PHENYLTHIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | PON1, NUDT1, HPRT1 | SLC22A12 450/4885MKNK1 3856/4885MKNK2 4060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.