Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5383966 | 0.89 | CSNK1D (0.49) | ADORA2AADORA1MAPK1TGFBR1ROCK2 | |
| SCHEMBL15026753 | 0.86 | ADORA2A (0.42) | ADORA2AADORA1RAB9ANPC1POLB | |
| SCHEMBL15025603 | 0.84 | TGFBR1 (0.47) | ADORA2AADORA1RAB9ANPC1POLB | |
| SCHEMBL15025491 | 0.82 | AOC3 (0.46) | ADORA2AADORA1RAB9ANPC1POLB | |
| SCHEMBL2221940 | 0.81 | RAB9A (0.44) | RAB9ANPC1POLBMEN1MAPT | |
| SCHEMBL15026752 | 0.80 | DDX3X (0.43) | ADORA2AADORA1RAB9ANPC1POLB | |
| SCHEMBL5372338 | 0.79 | CSNK1D (0.49) | ADORA2AADORA1MAPK1ROCK2RET | |
| SCHEMBL15025171 | 0.78 | SUCNR1 (0.43) | ADORA2AADORA1RAB9ANPC1POLB | |
| SCHEMBL15025173 | 0.78 | NPY2R (0.41) | ADORA2AADORA1RAB9ANPC1MEN1 | |
| SCHEMBL5378295 | 0.78 | CSNK1D (0.51) | ADORA2AMAPK1ROCK2RETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889677-B2 | Substituted triazoles useful as mGlu5 receptor modulators | Boehringer Ingellheim International GmbH (DE) | 2014-11-18 | — | — | US | disclosed |
| US-8642774-B2 | Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-04 | — | — | US | disclosed |
| US-20130184248-A1 | NOVEL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-07-18 | — | — | US | disclosed |
| US-20130150341-A1 | NOVEL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150341-A1 | NOVEL COMPOUNDS | GRM5, GRM1, GRIK5 | ADORA2A 79/4885ADORA1 77/4885RAB9A 732/4885 |
| US-20130184248-A1 | NOVEL COMPOUNDS | GRM5, GRIN1, GRM1 | ADORA2A 48/4885ADORA1 54/4885RAB9A 665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.