Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.32 |
| ▸ | BCL6 | P41182 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1503103 | 0.86 | DPP4 (0.37) | BCL6 | |
| Hydrochloric Acid SCHEMBL1503025 | 0.84 | DPP4 (0.37) | GRM2 | |
| Hydrochloric Acid SCHEMBL1502948 | 0.81 | GRM2 (0.37) | GRM2 | |
| Hydrochloric Acid SCHEMBL1503180 | 0.80 | PPARA (0.32) | GRM2 | |
| Hydrochloric Acid SCHEMBL1502998 | 0.79 | ACKR3 (0.34) | GRM2BCL6 | |
| Hydrochloric Acid SCHEMBL1503007 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL1502913 | 0.75 | GRM2 (0.60) | GRM2 | |
| SCHEMBL6890782 | 0.65 | GRM2 (0.55) | GRM2 | |
| SCHEMBL6893120 | 0.64 | GRM2 (0.55) | GRM2 | |
| Hydrochloric Acid SCHEMBL1503100 | 0.63 | GRM2 (0.52) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |