Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 3/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.30 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1502998 | 0.85 | ACKR3 (0.34) | GRM2ACKR3PPARAUSP30P2RY12 | |
| Hydrochloric Acid SCHEMBL1503180 | 0.83 | PPARA (0.32) | GRM2ACKR3PPARA | |
| Hydrochloric Acid SCHEMBL1502914 | 0.81 | GRM2 (0.33) | GRM2 | |
| SCHEMBL6889424 | 0.78 | GRM2 (0.59) | GRM2 | |
| Hydrochloric Acid SCHEMBL1502945 | 0.77 | GRM2 (0.58) | GRM2 | |
| Hydrochloric Acid SCHEMBL1503103 | 0.74 | DPP4 (0.37) | USP30KCNH2 | |
| Hydrochloric Acid SCHEMBL1503025 | 0.74 | DPP4 (0.37) | GRM2USP30 | |
| Hydrochloric Acid SCHEMBL1503007 | 0.71 | — | — | |
| SCHEMBL6891956 | 0.64 | GRM2 (0.58) | GRM2 | |
| SCHEMBL6893516 | 0.63 | GRM2 (0.54) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | claimed |
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |