Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 10/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1503103 | 0.85 | DPP4 (0.37) | DPP4USP30 | |
| Hydrochloric Acid SCHEMBL1502914 | 0.84 | GRM2 (0.33) | GRM2 | |
| Hydrochloric Acid SCHEMBL1503024 | 0.78 | GRM2 (0.54) | DPP4GRM2 | |
| Hydrochloric Acid SCHEMBL1502998 | 0.76 | ACKR3 (0.34) | USP30GRM2 | |
| Hydrochloric Acid SCHEMBL1503180 | 0.75 | PPARA (0.32) | GRM2 | |
| Hydrochloric Acid SCHEMBL1502948 | 0.74 | GRM2 (0.37) | USP30GRM2 | |
| Hydrochloric Acid SCHEMBL1503007 | 0.70 | — | — | |
| SCHEMBL1502985 | 0.69 | GRM2 (0.53) | DPP4GRM2 | |
| SCHEMBL6891799 | 0.68 | GRM2 (0.56) | GRM2 | |
| SCHEMBL24493087 | 0.66 | EGLN2 (0.56) | USP30VNN1EGLN2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | claimed |