Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | NAMPT | P43490 | 8/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15030897 | 0.84 | NPC1 (0.65) | NPC1NAMPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL165038 | 0.80 | NAMPT (1.00) | NAMPTHDAC1 | |
| SCHEMBL29635786 | 0.80 | NAMPT (1.00) | NAMPTHDAC1 | |
| SCHEMBL164472 | 0.79 | NAMPT (1.00) | NAMPTHDAC1 | |
| SCHEMBL18291355 | 0.79 | NAMPT (0.53) | NAMPTHDAC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL874752 | 0.78 | NAMPT (0.52) | NAMPTHDAC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL18286275 | 0.78 | GABRP (0.61) | NAMPTHDAC1SMN1; SMN2 | |
| SCHEMBL14617679 | 0.77 | PPIB (0.58) | NPC1NAMPTHDAC1RAB9ASMN1; SMN2 | |
| SCHEMBL10290541 | 0.77 | NAMPT (0.84) | NAMPTSMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL3154000 | 0.76 | MASP2 (0.50) | NAMPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012031196-A9 | 4- { [ ( PYRIDIN- 3 - YL -METHYL) AMINOCARBONYL] AMINO} BENZENE - SULFONE DERIVATIVES AS NAMPT INHIBITORS FOR THERAPY OF DISEASES SUCH AS CANCER | FORMA TM, LLC (US) | 2013-06-13 | — | — | WO | disclosed |