Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875947 | 0.89 | PPARA (0.49) | NAMPTHDAC1PPARASMN1; SMN2ALDH1A1 | |
| SCHEMBL874398 | 0.89 | NAMPT (0.50) | NAMPTHDAC1PPARAALDH1A1GAA | |
| SCHEMBL874266 | 0.85 | NAMPT (0.49) | NAMPTHDAC1PPARAPOLBMEN1 | |
| SCHEMBL874891 | 0.81 | HDAC1 (0.50) | NAMPTHDAC1MAPTPOLB | |
| SCHEMBL874692 | 0.80 | NAMPT (0.53) | NAMPTHDAC1PPARAPPARGPPARD | |
| SCHEMBL15030902 | 0.78 | NPC1 (0.68) | NAMPTHDAC1SMN1; SMN2HPGDMAPT | |
| SCHEMBL875487 | 0.77 | HDAC1 (0.45) | NAMPTHDAC1PPARASMN1; SMN2ALDH1A1 | |
| SCHEMBL10069647 | 0.77 | NAMPT (0.47) | NAMPTHDAC1PPARAPPARGPPARD | |
| SCHEMBL875702 | 0.76 | NAMPT (0.44) | NAMPTHDAC1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL875577 | 0.76 | HDAC1 (0.43) | NAMPTHDAC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |