Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 6/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.40 |
| ▸ | PARG | Q86W56 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503038 | 0.84 | GRM2 (0.61) | GRM2TSHRMAPTPARGLMNA | |
| SCHEMBL1502926 | 0.83 | GRM2 (0.64) | ALDH1A1GRM2TSHRMAPTPARG | |
| SCHEMBL1502968 | 0.83 | GRM2 (0.64) | ALDH1A1GRM2TSHRMAPTPARG | |
| SCHEMBL1502974 | 0.83 | GRM2 (0.64) | ALDH1A1GRM2TSHRMAPTPARG | |
| SCHEMBL6892275 | 0.81 | GRM2 (0.69) | ALDH1A1GRM2TSHRMAPTSMN1; SMN2 | |
| SCHEMBL6891162 | 0.81 | GRM2 (0.50) | ALDH1A1GRM2TSHRPARG | |
| SCHEMBL6891440 | 0.78 | GRM2 (0.49) | ALDH1A1GRM2TSHRMAPTSMN1; SMN2 | |
| SCHEMBL6891297 | 0.74 | GRM2 (0.47) | GRM2MAPTGRIN1GRIN2BPARG | |
| SCHEMBL6891306 | 0.74 | GRM2 (0.52) | ALDH1A1GRM2TSHRSMN1; SMN2PARG | |
| SCHEMBL6893791 | 0.74 | GRM2 (0.52) | ALDH1A1GRM2TSHRSMN1; SMN2PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | claimed |
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |