⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15007427 | 0.92 | GPR119 (0.32) | — | |
| SCHEMBL15031508 | 0.91 | — | — | |
| SCHEMBL21070 | 0.91 | DGAT1 (0.30) | — | |
| SCHEMBL15031506 | 0.85 | — | — | |
| SCHEMBL15026298 | 0.84 | GPR119 (0.33) | — | |
| SCHEMBL15007297 | 0.84 | GPR119 (0.33) | — | |
| SCHEMBL15007296 | 0.84 | GPR119 (0.33) | — | |
| SCHEMBL15007178 | 0.83 | DGAT1 (0.30) | — | |
| SCHEMBL12503604 | 0.82 | DGAT1 (0.32) | — | |
| SCHEMBL15026299 | 0.82 | DGAT1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130150362-A1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-06-13 | — | — | US | disclosed |
| US-20130150362-A1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-06-13 | — | — | US | disclosed |