SCHEMBL1503255

SCHEMBL1503255

C=CC(C(=O)CN)C1(C(=O)O)CCCN1

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ARG1 P05089 1/20 0.30
ARG2 P78540 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28904611 0.78
SCHEMBL13715066 0.67 ARG1 (0.34) ARG1ARG2
SCHEMBL8016763 0.67 ARG1 (0.34) ARG1ARG2
SCHEMBL1818488 0.63 AKR1C1 (0.37)
SCHEMBL23884534 0.63 AKR1C1 (0.37)
SCHEMBL13715084 0.62 ARG1 (0.30) ARG1ARG2
SCHEMBL7981038 0.62
Hydrochloric Acid SCHEMBL4684924 0.62 ARG1 (0.47) ARG1ARG2
Hydrochloric Acid SCHEMBL30382824 0.62 ARG1 (0.47) ARG1ARG2
SCHEMBL11239413 0.61 LMNA (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240132511-A1 TREATMENTS OF PRADER-WILLI SYNDROME NEUREN PHARMACEUTICALS LIMITED (NZ) 2024-04-25 US disclosed
EP-4291192-A1 TREATMENTS OF PRADER-WILLI SYNDROME Neuren Pharmaceuticals Limited (NZ) 2023-12-20 EP disclosed
US-20150258091-A1 CYCLIC GLYCYL-2-ALLYL PROLINE IMPROVES COGNITIVE PERFORMANCE IN IMPAIRED ANIMALS NEUREN PHARMACEUTICALS LIMITED (NZ) 2015-09-17 US disclosed
US-9119851-B2 Cyclic Glycyl-2-Allyl Proline improves cognitive performance in impaired animals NEUREN PHARMACEUTICALS, LTD. (NZ) 2015-09-01 US disclosed
US-20140309230-A1 Cyclic Glycyl-2-Allyl Proline Improves Cognitive Performance in Impaired Animals NEUREN PHARMACEUTICALS LIMITED (NZ) 2014-10-16 US disclosed
US-8791117-B2 Cyclic glycyl-2-allyl proline improves cognitive performance in impaired animals NEUREN PHARMACEUTICALS LIMITED (NZ) 2014-07-29 US disclosed
US-8519127-B2 Cyclic glycyl-2-allyl proline and its use in treatment of peripheral neuropathy NEUREN PHARMACEUTICALS LIMITED (AU) 2013-08-27 US disclosed
US-20110201614-A1 CYCLIC GLYCYL-2-ALLYL PROLINE IMPROVES COGNITIVE PERFORMANCE IN IMPAIRED ANIMALS NEUREN PHARMACEUTICALS LIMITED (AU) 2011-08-18 US disclosed
US-20110052531-A1 CYCLIC GLYCYL-2-ALLYL PROLINE AND ITS USE IN TREATMENT OF PERIPHERAL NEUROPATHY NEUREN PHARMACEUTICALS LIMITED (AU) 2011-03-03 US disclosed
US-20090263334-A1 Cyclic Glycyl-2-Allyl Proline Improves Cognitive Performance in Impaired Animals BICKERDIKE MIKE JOHN 2009-10-22 US disclosed
WO-2008063311-A2 CYCLIC GLYCYL-2-ALLYL PROLINE IMPROVES COGNITIVE PERFORMANCE IN IMPAIRED ANIMALS NEUREN PHARMACEUTICALS LIMITED (NZ) 2008-05-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110052531-A1 CYCLIC GLYCYL-2-ALLYL PROLINE AND ITS USE IN TREATMENT OF PERIPHERAL NEUROPATHY PMP22, IAPP, GCG ARG1 2600/4885ARG2 678/4885
US-20240132511-A1 TREATMENTS OF PRADER-WILLI SYNDROME COMT, HSD17B3, HSD3B1 ARG1 3293/4885ARG2 3099/4885
US-20110201614-A1 CYCLIC GLYCYL-2-ALLYL PROLINE IMPROVES COGNITIVE PERFORMANCE IN IMPAIRED ANIMALS GRIA2, QPCT, GRM2 ARG1 723/4885ARG2 226/4885
US-20090263334-A1 Cyclic Glycyl-2-Allyl Proline Improves Cognitive Performance in Impaired Animals GRIA2, QPCT, GRM2 ARG1 723/4885ARG2 226/4885
US-20140309230-A1 Cyclic Glycyl-2-Allyl Proline Improves Cognitive Performance in Impaired Animals GRIA2, QPCT, GRM2 ARG1 723/4885ARG2 226/4885
US-20150258091-A1 CYCLIC GLYCYL-2-ALLYL PROLINE IMPROVES COGNITIVE PERFORMANCE IN IMPAIRED ANIMALS GRIA2, GRIN2A, QPCT ARG1 1043/4885ARG2 369/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.