Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.33 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503300 | 0.92 | ADAMTS4 (0.37) | SCN9ASCN5AADAMTS4MMP2MMP13 | |
| SCHEMBL2220322 | 0.89 | ALDH1A1 (0.40) | SCN9ASCN5AALDH1A1KMT2AMEN1 | |
| SCHEMBL1503187 | 0.83 | ALDH1A1 (0.41) | ALDH1A1PARP10KMT2AMEN1GAA | |
| SCHEMBL22738223 | 0.82 | SCN9A (0.41) | SCN9ASCN5AMAPTMAOBMAOA | |
| SCHEMBL30954808 | 0.82 | HDAC1 (0.41) | SCN9ASCN5AMAPTMAOB | |
| SCHEMBL1503267 | 0.82 | HDAC1 (0.41) | SCN9ASCN5AMAPTMAOB | |
| SCHEMBL22719903 | 0.80 | GRIN1 (0.43) | SCN9ASCN5AALDH1A1KLKB1LMNA | |
| SCHEMBL22738285 | 0.79 | MEN1 (0.40) | SCN9ASCN5AKMT2AMEN1KLKB1 | |
| SCHEMBL4304503 | 0.78 | PPARG (0.41) | SCN9ASCN5AMAPTMAOBMAOA | |
| SCHEMBL1503165 | 0.77 | ALDH1A1 (0.41) | SCN9ASCN5AALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300433-A1 | HIV INTEGRASE INHIBITORS FROM PYRIDOXINE | Ambrilia Biopharma Inc. (CA) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009146555-A1 | HIV INTEGRASE INHIBITORS FROM PYRIDOXINE | AMBRILIA BIOPHARMA INC. (CA) | 2009-12-10 | — | — | WO | disclosed |