Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22738285 | 0.92 | MEN1 (0.40) | KLKB1EGLN1EGLN2SCN9AMAPT | |
| SCHEMBL22738223 | 0.88 | SCN9A (0.41) | EGLN1EGLN2SCN9AMAPTSCN5A | |
| SCHEMBL30954808 | 0.87 | HDAC1 (0.41) | EGLN1EGLN2SCN9AMAPTSCN5A | |
| SCHEMBL1503267 | 0.87 | HDAC1 (0.41) | EGLN1EGLN2SCN9AMAPTSCN5A | |
| SCHEMBL22738288 | 0.86 | GABRA5 (0.42) | GRIN2BEGLN1EGLN2MAPTLMNA | |
| SCHEMBL2220322 | 0.86 | ALDH1A1 (0.40) | SCN9AMAPTHTTSCN5AALDH1A1 | |
| SCHEMBL22719900 | 0.84 | GRIN1 (0.40) | GRIN1GRIN2BEGLN1SCN9ASCN5A | |
| SCHEMBL4304503 | 0.83 | PPARG (0.41) | SCN9AMAPTSCN5A | |
| SCHEMBL1503300 | 0.83 | ADAMTS4 (0.37) | SCN9AMAPTSCN5ACYP2C19ALDH1A1 | |
| SCHEMBL1503299 | 0.80 | SCN9A (0.36) | KLKB1SCN9AMAPTSCN5ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |