Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.83 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL154378 | 1.00 | MAPT (0.83) | MAPTPOLBHRH3ALDH1A1PKM | |
| SCHEMBL146416 | 0.98 | MAPT (0.86) | MAPTPOLBHRH3ALDH1A1PKM | |
| SCHEMBL151103 | 0.93 | MAPT (0.95) | MAPTPOLBHRH3ALDH1A1PKM | |
| SCHEMBL151720 | 0.93 | MAPT (0.95) | MAPTPOLBHRH3ALDH1A1PKM | |
| SCHEMBL27895291 | 0.93 | — | — | |
| SCHEMBL6738785 | 0.91 | MAPT (0.91) | MAPTPOLBHRH3ALDH1A1PKM | |
| SCHEMBL7228795 | 0.91 | MAPT (0.91) | MAPTPOLBHRH3ALDH1A1PKM | |
| SCHEMBL9322332 | 0.91 | MAPT (0.91) | MAPTPOLBHRH3ALDH1A1PKM | |
| SCHEMBL149979 | 0.91 | MAPT (1.00) | MAPTPOLBHRH3ALDH1A1PKM | |
| SCHEMBL9206204 | 0.88 | MAPT (0.95) | MAPTPOLBHRH3ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5731435-A | Process for the preparation of heterocyclic alkylamide derivatives | G. D. SEARLE & CO. (US) | 1998-03-24 | — | — | US | claimed |
| EP-0063075-B1 | (2,6-DIMETHOXY-4-HYDROXYPHENYL)-(3-PIPERIDINOPROPYL) KETONE AND ITS SALTS, ITS USE IN THERAPEUTIC PREPARATIONS AND PROCESS FOR ITS PRODUCTION | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1984-07-04 | — | — | EP | claimed |
| US-4404167-A | AMINO NITRILE INHIBITORS | ROZENFELD IOSIF L | 1983-09-13 | — | — | US | claimed |
| EP-0063075-A1 | (2,6-Dimethoxy-4-hydroxyphenyl)-(3-piperidinopropyl) ketone and its salts, its use in therapeutic preparations and process for its production | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1982-10-20 | — | — | EP | claimed |
| CN-105189446-B | Phloroglucin analog derivative and its purposes in treating neurodegenerative disease | 中国医学科学院药物研究所 | 2018-07-20 | — | — | CN | disclosed |
| US-9469710-B2 | Polymers functionalized with nitrile compounds containing a protected amino group | BRIDGESTONE CORPORATION (JP) | 2016-10-18 | — | — | US | disclosed |
| CN-105189446-A | Phloroglucinol derivatives and application thereof in treatment of neurodegenerative disorder | INST MATERIA MEDICA CAMS | 2015-12-23 | — | — | CN | disclosed |
| CN-103333275-B | With the polymkeric substance of functionalized with nitrile compounds comprising protected amino | BRIDGESTONE CO., LTD. (JP) | 2015-07-29 | — | — | CN | disclosed |
| US-20150148489-A1 | POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP | BRIDGESTONE CORPORATION (JP) | 2015-05-28 | — | — | US | disclosed |
| US-8735494-B2 | Polymers functionalized with nitrile compounds containing a protected amino group | BRIDGESTONE CORPORATION (JP) | 2014-05-27 | — | — | US | disclosed |
| CN-103333275-A | Polymers functionalized with nitrile compounds containing a protected amino group | BRIDGESTONE CORP | 2013-10-02 | — | — | CN | disclosed |
| CN-102361887-B | Polymers functionalized with nitrile compounds containing a protected amino group | BRIDGESTONE CORP | 2013-06-26 | — | — | CN | disclosed |
| US-5217979-A | Substituted alkyl piperidines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-08 | — | — | US | disclosed |
| US-5153327-A | 7-Oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease | E. R. SQUIBB & SONS, INC. (US) | 1992-10-06 | — | — | US | disclosed |
| US-5100889-A | Thromboxane A2 receptor antagonists, thromboxane synthetase inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1992-03-31 | — | — | US | disclosed |
| EP-0420116-A2 | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMACEUTICALS INC. (US) | 1991-04-03 | — | — | EP | disclosed |
| EP-0063075-B1 | (2,6-DIMETHOXY-4-HYDROXYPHENYL)-(3-PIPERIDINOPROPYL) KETONE AND ITS SALTS, ITS USE IN THERAPEUTIC PREPARATIONS AND PROCESS FOR ITS PRODUCTION | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1984-07-04 | — | — | EP | disclosed |
| US-4404167-A | AMINO NITRILE INHIBITORS | ROZENFELD IOSIF L | 1983-09-13 | — | — | US | disclosed |
| EP-0063075-A1 | (2,6-Dimethoxy-4-hydroxyphenyl)-(3-piperidinopropyl) ketone and its salts, its use in therapeutic preparations and process for its production | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1982-10-20 | — | — | EP | disclosed |
| EP-0063075-A1 | (2,6-Dimethoxy-4-hydroxyphenyl)-(3-piperidinopropyl) ketone and its salts, its use in therapeutic preparations and process for its production | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1982-10-20 | — | — | EP | disclosed |