Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15022718 | 0.89 | TRPV3 (0.38) | TRPV3PTGS2PTGS1KDM4EALDH1A1 | |
| SCHEMBL15751164 | 0.88 | PTGS1 (0.39) | TRPV3PTGS2PTGS1NPY5RALDH1A1 | |
| SCHEMBL15751090 | 0.88 | TRPV3 (0.38) | TRPV3PTGS2PTGS1KDM4EALDH1A1 | |
| SCHEMBL15750938 | 0.87 | TRPV3 (0.41) | TRPV3PTGS2PTGS1KDM4EALDH1A1 | |
| SCHEMBL15750923 | 0.86 | GABRA1 (0.41) | TRPV3KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL15751082 | 0.86 | ALDH1A1 (0.44) | TRPV3PTGS2KDM4EALDH1A1MEN1 | |
| SCHEMBL15021817 | 0.85 | TRPV3 (0.39) | TRPV3PTGS2PTGS1NPY5RKDM4E | |
| SCHEMBL15750979 | 0.85 | TRPV3 (0.43) | TRPV3PTGS2KDM4EALDH1A1NPC1 | |
| SCHEMBL15750928 | 0.85 | TRPV3 (0.35) | TRPV3PTGS2PTGS1NPC1RAB9A | |
| SCHEMBL15751005 | 0.85 | PTGS1 (0.40) | TRPV3PTGS2PTGS1NPY5RKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2738172-A1 | New bicyclic compounds as crac channel modulators | Almirall, S.A. (ES) | 2014-06-04 | — | — | EP | disclosed |
| WO-2013092463-A1 | 4-AZAINDOLE INHIBITORS OF CRAC | F. HOFFMANN-LA ROCHE AG (CH) | 2013-06-27 | — | — | WO | disclosed |
| US-20130158066-A1 | 4-AZAINDOLE INHIBITORS OF CRAC | HOFFMANN-LA ROCHE INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-20130158066-A1 | 4-AZAINDOLE INHIBITORS OF CRAC | HOFFMANN-LA ROCHE INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158066-A1 | 4-AZAINDOLE INHIBITORS OF CRAC | ORAI1, CACNA1I, RYR2 | TRPV3 143/4885PTGS2 154/4885PTGS1 368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.