Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503635 | 0.87 | NPC1 (0.49) | ALDH1A1PKMCNR2CNR1MAPT | |
| SCHEMBL1504684 | 0.82 | ALDH1A1 (0.42) | ALDH1A1PKMKDM4ECNR2CNR1 | |
| SCHEMBL1503561 | 0.81 | ADAM17 (0.58) | ALDH1A1PKML3MBTL1MAPTHPGD | |
| SCHEMBL1503650 | 0.81 | ALDH1A1 (0.59) | ALDH1A1PKMNAMPTL3MBTL1KDM4E | |
| SCHEMBL2680367 | 0.78 | KMT2A (0.52) | ALDH1A1PKML3MBTL1MEN1TSHR | |
| SCHEMBL16565833 | 0.76 | ALDH1A1 (0.67) | ALDH1A1PKMNAMPTL3MBTL1KDM4E | |
| SCHEMBL17886704 | 0.75 | ALDH1A1 (0.69) | ALDH1A1PKMNAMPTL3MBTL1KDM4E | |
| SCHEMBL17888350 | 0.75 | ALDH1A1 (0.69) | ALDH1A1PKMNAMPTL3MBTL1KDM4E | |
| SCHEMBL9291268 | 0.72 | ALDH1A1 (0.70) | ALDH1A1PKML3MBTL1KDM4EMAPT | |
| SCHEMBL1503621 | 0.72 | USP2 (0.46) | ALDH1A1L3MBTL1KDM4EMAPTCD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033010-A1 | 4-ALKOXY-N- (2-HYDROXYCARBAMOYL-2-PIPERIDINYL-ETHYL) -BENZAMIDE COMPOUNDS AS SELECTIVE TACE-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |