Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503623 | 0.90 | ALDH1A1 (0.46) | ALDH1A1KMT2ACTNNB1POLBRAB9A | |
| SCHEMBL1504825 | 0.88 | ALDH1A1 (0.45) | ALDH1A1KMT2ACTNNB1POLBRAB9A | |
| SCHEMBL1504784 | 0.85 | ADAM17 (0.43) | ALDH1A1POLBTP53 | |
| SCHEMBL1504823 | 0.83 | ALDH1A1 (0.41) | ALDH1A1TSHRPKMCTNNB1POLB | |
| SCHEMBL1503540 | 0.81 | ALDH1A1 (0.53) | ALDH1A1TSHRPKMKMT2ANAMPT | |
| SCHEMBL1503561 | 0.80 | ADAM17 (0.58) | ALDH1A1PKMKMT2AL3MBTL1 | |
| SCHEMBL10475892 | 0.77 | ADAM17 (0.53) | ALDH1A1TSHRKMT2ACTNNB1TP53 | |
| SCHEMBL10475894 | 0.77 | ADAM17 (0.53) | ALDH1A1TSHRKMT2ACTNNB1TP53 | |
| SCHEMBL1503541 | 0.75 | ADAM17 (0.53) | ALDH1A1TSHRKMT2ACTNNB1TP53 | |
| SCHEMBL1503642 | 0.75 | ADAM17 (0.53) | ALDH1A1TSHRKMT2ACTNNB1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033010-A1 | 4-ALKOXY-N- (2-HYDROXYCARBAMOYL-2-PIPERIDINYL-ETHYL) -BENZAMIDE COMPOUNDS AS SELECTIVE TACE-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |