Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.53 |
| ▸ | LOX | P28300 | 7/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 7/20 | 0.48 |
| ▸ | LOXL3 | P58215 | 4/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15036781 | 0.90 | LOX (0.48) | MRGPRX4LOXLOXL2LOXL3CYP1A2 | |
| SCHEMBL16939952 | 0.89 | HSD17B10 (0.47) | MRGPRX4LOXLOXL2LOXL3PDK2 | |
| SCHEMBL15036865 | 0.84 | HPGD (0.60) | ALDH1A1RECQLLMNAPOLBHPGD | |
| SCHEMBL30804719 | 0.80 | L3MBTL3 (0.54) | PDK2ALDH1A1HSD11B1MGLLMEN1 | |
| SCHEMBL14060831 | 0.78 | MRGPRX4 (0.47) | MRGPRX4LOXL2PDK2KMT2A | |
| SCHEMBL2946154 | 0.76 | NR4A2 (0.63) | MRGPRX4KMT2A | |
| SCHEMBL30281213 | 0.76 | NR4A2 (0.63) | MRGPRX4KMT2A | |
| SCHEMBL2714234 | 0.75 | MAOB (0.66) | MEN1KMT2A | |
| SCHEMBL15036779 | 0.75 | PARP1 (0.56) | MRGPRX4CYP1A2CYP2C9KDM4ELMNA | |
| SCHEMBL1807570 | 0.74 | HRH1 (0.54) | HSD11B1MGLLPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663510-B2 | Substituted triazolopyridines and their use as TTK inhibitors | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-05-30 | — | — | US | disclosed |
| US-9663510-B2 | Substituted triazolopyridines and their use as TTK inhibitors | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-05-30 | — | — | US | disclosed |
| US-20160120854-A1 | PHARMACEUTICAL COMPOSITIONS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-05-05 | — | — | US | disclosed |
| US-20160120854-A1 | PHARMACEUTICAL COMPOSITIONS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-05-05 | — | — | US | disclosed |
| US-20150210683-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND THEIR USE AS TTK INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-07-30 | — | — | US | disclosed |
| US-20150210683-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND THEIR USE AS TTK INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-07-30 | — | — | US | disclosed |
| EP-2791136-B1 | SUBSTITUTED TRIAZOLOPYRIDINES AND THEIR USE AS TTK INHIBITORS | BAYER IP GMBH (DE) | 2015-07-29 | — | — | EP | disclosed |
| WO-2013087579-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND THEIR USE AS TTK INHIBITORS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210683-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND THEIR USE AS TTK INHIBITORS | TTK, TXK, ITK | MRGPRX4 905/4885LOX 2435/4885LOXL2 3504/4885 |
| US-20160120854-A1 | PHARMACEUTICAL COMPOSITIONS | CYP3A5, CYP2C19, CYP3A7 | MRGPRX4 587/4885LOX 2982/4885LOXL2 3948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.