Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 4/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30804719 | 0.84 | L3MBTL3 (0.54) | MEN1KMT2AHTTGAAALDH1A1 | |
| SCHEMBL15036780 | 0.84 | MRGPRX4 (0.53) | HPGDLMNAPOLBMEN1KMT2A | |
| SCHEMBL15036781 | 0.84 | LOX (0.48) | HPGDLMNAPOLBMEN1KMT2A | |
| SCHEMBL16939952 | 0.83 | HSD17B10 (0.47) | LMNAPOLBMEN1KMT2AHTT | |
| SCHEMBL29944002 | 0.81 | RAB9A (0.73) | HPGDLMNAPOLBMEN1KMT2A | |
| SCHEMBL24627425 | 0.80 | MEN1 (0.60) | HPGDLMNAPOLBMEN1KMT2A | |
| SCHEMBL7864765 | 0.80 | MEN1 (0.60) | HPGDLMNAPOLBMEN1KMT2A | |
| SCHEMBL7873479 | 0.78 | MEN1 (0.59) | HPGDLMNAPOLBMEN1KMT2A | |
| SCHEMBL1807570 | 0.78 | HRH1 (0.54) | POLBMEN1KMT2AGAARAB9A | |
| SCHEMBL2946154 | 0.78 | NR4A2 (0.63) | KMT2ANPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663510-B2 | Substituted triazolopyridines and their use as TTK inhibitors | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-05-30 | — | — | US | disclosed |
| US-9663510-B2 | Substituted triazolopyridines and their use as TTK inhibitors | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-05-30 | — | — | US | disclosed |
| US-20160120854-A1 | PHARMACEUTICAL COMPOSITIONS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-05-05 | — | — | US | disclosed |
| US-20160120854-A1 | PHARMACEUTICAL COMPOSITIONS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-05-05 | — | — | US | disclosed |
| US-20150210683-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND THEIR USE AS TTK INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-07-30 | — | — | US | disclosed |
| US-20150210683-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND THEIR USE AS TTK INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-07-30 | — | — | US | disclosed |
| EP-2791136-B1 | SUBSTITUTED TRIAZOLOPYRIDINES AND THEIR USE AS TTK INHIBITORS | BAYER IP GMBH (DE) | 2015-07-29 | — | — | EP | disclosed |
| WO-2013087579-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND THEIR USE AS TTK INHIBITORS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210683-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND THEIR USE AS TTK INHIBITORS | TTK, TXK, ITK | HPGD 1439/4885LMNA 1519/4885POLB 1461/4885 |
| US-20160120854-A1 | PHARMACEUTICAL COMPOSITIONS | CYP3A5, CYP2C19, CYP3A7 | HPGD 135/4885LMNA 1549/4885POLB 2837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.