Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 2/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.41 |
| ▸ | MIF | P14174 | 2/20 | 0.40 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15244877 | 0.94 | KEAP1 (0.55) | KEAP1NFE2L2HSD17B1HSD17B2STS | |
| SCHEMBL15036894 | 0.90 | CYP1B1 (0.58) | KEAP1NFE2L2CYP1B1STSMIF | |
| SCHEMBL15036885 | 0.89 | KEAP1 (0.44) | KEAP1NFE2L2CYP1B1HSD17B1HSD17B2 | |
| SCHEMBL16603465 | 0.88 | KEAP1 (0.55) | KEAP1NFE2L2CYP1B1HSD17B1HSD17B2 | |
| SCHEMBL15036891 | 0.88 | CYP1B1 (0.41) | KEAP1NFE2L2CYP1B1HSD17B1HSD17B2 | |
| SCHEMBL15036900 | 0.87 | KEAP1 (0.48) | KEAP1NFE2L2HSD17B1HSD17B2STS | |
| SCHEMBL15274989 | 0.84 | CYP1B1 (0.56) | KEAP1NFE2L2CYP1B1STSMIF | |
| SCHEMBL15274988 | 0.84 | CYP1B1 (0.56) | KEAP1NFE2L2CYP1B1STSMIF | |
| SCHEMBL15036884 | 0.82 | KEAP1 (0.42) | KEAP1NFE2L2CYP1B1HSD17B1HSD17B2 | |
| SCHEMBL15274991 | 0.82 | KEAP1 (0.49) | KEAP1NFE2L2HSD17B1HSD17B2STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9469616-B2 | Cyclic compounds and methods of making and using the same | CELLCEUTIX CORPORATION (US) | 2016-10-18 | — | — | US | disclosed |
| US-9469616-B2 | Cyclic compounds and methods of making and using the same | CELLCEUTIX CORPORATION (US) | 2016-10-18 | — | — | US | disclosed |
| US-20150031738-A1 | CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | UNIVERSITY OF MASSACHUSETTS (US) | 2015-01-29 | — | — | US | disclosed |
| US-20150031738-A1 | CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | UNIVERSITY OF MASSACHUSETTS (US) | 2015-01-29 | — | — | US | disclosed |
| WO-2013090185-A1 | CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | POLYMEDIX, INC. (US) | 2013-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031738-A1 | CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MUC1, TLR3, ALG1 | KEAP1 1835/4885NFE2L2 4399/4885CYP1B1 4315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.