Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.58 |
| ▸ | STS | P08842 | 4/20 | 0.41 |
| ▸ | MIF | P14174 | 4/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 3/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA5A | P35218 | 2/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15274988 | 0.94 | CYP1B1 (0.56) | CYP1B1STSMIFP2RY14STIM1 | |
| SCHEMBL15274989 | 0.94 | CYP1B1 (0.56) | CYP1B1STSMIFP2RY14STIM1 | |
| SCHEMBL15036886 | 0.90 | KEAP1 (0.48) | CYP1B1STSMIFSTIM1ORAI1 | |
| SCHEMBL15277742 | 0.89 | CYP1B1 (0.48) | CYP1B1STSMIFP2RY14OPRD1 | |
| SCHEMBL16419776 | 0.87 | CYP1B1 (0.47) | CYP1B1STSMIFP2RY14MAPT | |
| SCHEMBL15244877 | 0.83 | KEAP1 (0.55) | STSSTIM1ORAI1KEAP1NFE2L2 | |
| SCHEMBL15036891 | 0.83 | CYP1B1 (0.41) | CYP1B1STSMIFP2RY14STIM1 | |
| SCHEMBL16419752 | 0.82 | CYP1B1 (0.45) | CYP1B1STSMIFP2RY14CA1 | |
| SCHEMBL16419764 | 0.80 | CYP1B1 (0.49) | CYP1B1STSMIFP2RY14OPRD1 | |
| SCHEMBL15036885 | 0.79 | KEAP1 (0.44) | CYP1B1STSMIFP2RY14CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9469616-B2 | Cyclic compounds and methods of making and using the same | CELLCEUTIX CORPORATION (US) | 2016-10-18 | — | — | US | disclosed |
| US-9469616-B2 | Cyclic compounds and methods of making and using the same | CELLCEUTIX CORPORATION (US) | 2016-10-18 | — | — | US | disclosed |
| US-20160287586-A1 | COMPOUNDS AND METHODS FOR TREATING CANDIDIASIS AND ASPERGILLUS INFECTIONS | CELLCEUTIX CORPORATION | 2016-10-06 | — | — | US | disclosed |
| US-20150031738-A1 | CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | UNIVERSITY OF MASSACHUSETTS (US) | 2015-01-29 | — | — | US | disclosed |
| US-20150031738-A1 | CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | UNIVERSITY OF MASSACHUSETTS (US) | 2015-01-29 | — | — | US | disclosed |
| US-20130252964-A1 | Compounds And Methods For Treating Candidiasis And Aspergillus Infections | POLYMEDIX, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| WO-2013109827-A1 | COMPOUNDS AND METHODS FOR TREATING CANDIDIASIS AND ASPERGILLUS INFECTIONS | POLYMEDIX, INC. (US) | 2013-07-25 | — | — | WO | disclosed |
| WO-2013090185-A1 | CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | POLYMEDIX, INC. (US) | 2013-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252964-A1 | Compounds And Methods For Treating Candidiasis And Aspergillus Infections | ERG28, DPM1, MANBA | CYP1B1 300/4885STS 879/4885MIF 690/4885 |
| US-20150031738-A1 | CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MUC1, TLR3, ALG1 | CYP1B1 4315/4885STS 1389/4885MIF 16/4885 |
| US-20160287586-A1 | COMPOUNDS AND METHODS FOR TREATING CANDIDIASIS AND ASPERGILLUS INFECTIONS | ERG28, DPM1, MANBA | CYP1B1 300/4885STS 879/4885MIF 690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.