Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8148844 | 0.84 | RECQL (0.46) | RECQLSMN1; SMN2POLBHTTKMT2A | |
| SCHEMBL28827551 | 0.80 | RECQL (0.44) | RECQLSMN1; SMN2POLBHTTKMT2A | |
| SCHEMBL27203361 | 0.80 | RECQL (0.44) | RECQLSMN1; SMN2POLBHTTKMT2A | |
| SCHEMBL21034083 | 0.80 | RECQL (0.44) | RECQLSMN1; SMN2POLBHTTKMT2A | |
| SCHEMBL28175124 | 0.80 | POLB (0.45) | RECQLSMN1; SMN2POLBHTTKMT2A | |
| SCHEMBL2053373 | 0.77 | KDM4E (0.45) | RECQLSMN1; SMN2POLBHTTKMT2A | |
| SCHEMBL5805673 | 0.76 | SMN1; SMN2 (0.36) | RECQLSMN1; SMN2HTTTSHRHTR6 | |
| SCHEMBL23701634 | 0.75 | KMT2A (0.41) | RECQLSMN1; SMN2POLBHTTKMT2A | |
| Sulfuric Acid SCHEMBL22462539 | 0.75 | RECQL (0.41) | RECQLSMN1; SMN2POLBHTTKMT2A | |
| SCHEMBL8636455 | 0.74 | ESR1 (0.45) | KDM4ETSHRALDH1A1RAB9ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912203-B2 | 6-(sulfonylaryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-12-16 | — | — | US | disclosed |
| US-20130252966-A1 | 6-(SULFONYLARYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | AFRAXIS, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| CN-1057091-C | Novelc arbapenem derivatives | MEIJI SEIKA CO (JP) | 2000-10-04 | — | — | CN | disclosed |
| CN-1148390-A | Novelc arbapenem derivatives | MEIJI SEIKA CO (JP) | 1997-04-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252966-A1 | 6-(SULFONYLARYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | PAK2, PAK6, PAK3 | RECQL 2409/4885SMN1; SMN2 423/4885POLB 4522/4885 |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | RECQL 1937/4885SMN1; SMN2 3156/4885POLB 2459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.