Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.55 |
| ▸ | MMP9 | P14780 | 3/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.55 |
| ▸ | MMP8 | P22894 | 2/20 | 0.55 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | IAPP | P10997 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15249303 | 0.84 | MMP2 (0.51) | MMP2MMP9NFKB1MMP8AKR1B10 | |
| SCHEMBL12291332 | 0.84 | FOS (0.67) | MMP2MMP9NFKB1MMP8AKR1B10 | |
| SCHEMBL12291330 | 0.84 | BACE1 (0.53) | MMP2MMP9NFKB1MMP8AKR1B10 | |
| SCHEMBL4544305 | 0.83 | BACE1 (0.68) | MMP2MMP9NFKB1MMP8AKR1B10 | |
| SCHEMBL12593153 | 0.83 | IAPP (0.67) | MMP2MMP9NFKB1MMP8AKR1B10 | |
| SCHEMBL30851321 | 0.83 | IAPP (0.67) | MMP2MMP9NFKB1AKR1B10AKR1B1 | |
| SCHEMBL20978310 | 0.83 | IAPP (0.67) | MMP2MMP9NFKB1AKR1B10AKR1B1 | |
| SCHEMBL16382586 | 0.82 | MAPT (0.58) | MMP2MMP9NFKB1MMP8AKR1B10 | |
| SCHEMBL12555874 | 0.82 | AKR1C3 (0.66) | MMP2MMP9NFKB1MMP8AKR1B10 | |
| SCHEMBL29395741 | 0.82 | AKR1C3 (0.66) | MMP2MMP9NFKB1MMP8AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9260473-B2 | Bivalent multifunctional ligands targeting Aβ oligomers as treatment for Alzheimer's disease | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2016-02-16 | — | — | US | disclosed |
| US-20130156705-A1 | BIVALENT MULTIFUNCTIONAL LIGANDS TARGETING A[BETA] OLIGOMERS AS TREATMENT FOR ALZHEIMER'S DISEASE | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130156705-A1 | BIVALENT MULTIFUNCTIONAL LIGANDS TARGETING A[BETA] OLIGOMERS AS TREATMENT FOR ALZHEIMER'S DISEASE | LDLR, NR1H2, MSR1 | MMP2 1876/4885MMP9 2314/4885NFKB1 1073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.