SCHEMBL1504379

SCHEMBL1504379

NC1c2ccccc2C2CCCCC12

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
NOS1 P29475 3/20 0.42
PPIA P62937 2/20 0.40
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
ESR1 P03372 2/20 0.38
ESR2 Q92731 2/20 0.38
NOS3 P29474 1/20 0.38
NOS2 P35228 1/20 0.38
PARP1 P09874 1/20 0.36
KDM1A O60341 5/20 0.35
KDM1B Q8NB78 1/20 0.35
HTR2A P28223 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3290310 0.77 MEN1 (0.56) NOS1PPIAMEN1KMT2ANOS3
SCHEMBL22879358 0.76 ANPEP (0.53) NOS1PARP1KDM1AHTR2A
SCHEMBL21311751 0.75 PPIA (0.40) NOS1PPIAMEN1KMT2AESR1
SCHEMBL7544039 0.75 NOS1 (0.42) NOS1PPIAMEN1KMT2AESR1
SCHEMBL12813351 0.75 PPIA (0.47) NOS1PPIAMEN1KMT2AESR1
SCHEMBL8894478 0.75 PPIA (0.40) NOS1PPIAMEN1KMT2AESR1
SCHEMBL6240869 0.73 ADRA2A (0.43) HTR2A
SCHEMBL14577672 0.72 PPIA (0.41) NOS1PPIAMEN1KMT2AESR1
SCHEMBL22625621 0.71 ESR1 (0.45) NOS1PPIAMEN1KMT2AESR1
SCHEMBL11619641 0.71 PPIA (0.38) NOS1PPIAMEN1KMT2AESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8575106-B2 Cosmetic uses of modified stressed yeast extracts and related compositions AVON PRODUCTS, INC. (US) 2013-11-05 US claimed
EP-2473183-A2 COSMETIC USES OF MODIFIED STRESSED YEAST EXTRACTS AND RELATED COMPOSITIONS Avon Products, Inc. (US) 2012-07-11 EP claimed
US-20110052517-A1 Cosmetic Uses of Modified Stressed Yeast Extracts and Related Compositions Avon Place (US) 2011-03-03 US claimed
WO-2011025635-A2 COSMETIC USES OF MODIFIED STRESSED YEAST EXTRACTS AND RELATED COMPOSITIONS AVON PRODUCTS, INC. (US) 2011-03-03 WO claimed
EP-2473183-B1 COSMETIC USES OF MODIFIED STRESSED YEAST EXTRACTS AND RELATED COMPOSITIONS AVON PROD INC (US) 2018-06-27 EP disclosed
EP-2890359-B1 DICKKOPF-1 EXPRESSION MODULATING COMPOSITIONS AND USES THEREOF AVON PROD INC (US) 2016-10-05 EP disclosed
EP-2890359-A1 DICKKOPF-1 EXPRESSION MODULATING COMPOSITIONS AND USES THEREOF Avon Products, Inc. (US) 2015-07-08 EP disclosed
US-9023327-B2 DICKKOPF-1 expression modulating compositions and uses thereof AVON PRODUCTS, INC. (US) 2015-05-05 US disclosed
US-20140065086-A1 Dickkopf-1 Expression Modulating Compositions and Uses Thereof AVON PRODUCTS, INC. (US) 2014-03-06 US disclosed
WO-2014035401-A1 DICKKOPF-1 EXPRESSION MODULATING COMPOSITIONS AND USES THEREOF AVON PRODUCTS, INC. (US) 2014-03-06 WO disclosed
US-8575106-B2 Cosmetic uses of modified stressed yeast extracts and related compositions AVON PRODUCTS, INC. (US) 2013-11-05 US disclosed
EP-2473183-A2 COSMETIC USES OF MODIFIED STRESSED YEAST EXTRACTS AND RELATED COMPOSITIONS Avon Products, Inc. (US) 2012-07-11 EP disclosed
US-20110052517-A1 Cosmetic Uses of Modified Stressed Yeast Extracts and Related Compositions Avon Place (US) 2011-03-03 US disclosed
WO-2011025635-A2 COSMETIC USES OF MODIFIED STRESSED YEAST EXTRACTS AND RELATED COMPOSITIONS AVON PRODUCTS, INC. (US) 2011-03-03 WO disclosed
US-20070105752-A1 Inhibition of the SRC kinase family pathway as a method of treating HBV infection and hepatocellular carcinoma NEW YORK UNIVERSITY MEDICAL CENTER 2007-05-10 US disclosed
WO-2006084005-A2 EMERGENCE OF A R-TYPE CA2+CHANNEL(CAV2.3) CONTRIBUTES TO CEREBRAL ARTERY CONSTRICTION FOLLOWING SUBARACHNOID HEMORRHAGE UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE (US) 2006-08-10 WO disclosed
US-20020045191-A1 Inhibition of the SRC kinase family pathway as a method of treating HBV infection and hepatocellular carcinoma NEW YORK UNIVERSITY 2002-04-18 US disclosed
US-5081304-A Diagnosis of neurodegenerative disorders WARNER-LAMBERT COMPANY (US) 1992-01-14 US disclosed
US-4960815-A CENTRAL NERVOUS SYSTEM DISORDERS WARNER-LAMBERT COMPANY (US) 1990-10-02 US disclosed